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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

    SBC: NEUROBEHAVIORAL SYSTEMS INC            Topic: NIA

    Abstract. Hispanic Americans are the largest and fastest growing US minority and, over coming decades, will show the largest relative increase in Alzheimer’s disease (AD) incidence of any ethnic group. However, Spanish-speaking Hispanics have been largely excluded from clinical trials and research studies for several reasons: (1) Only 5.5% of US neuropsychologists have sufficient fluency to admi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research

    SBC: SPIKEGADGETS, INC.            Topic: 101

    Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits of our brains. Yet, the exact nature of these abnormal patterns is often unknown to developers of new treatments. The goal of this project is to enable circuit-oriented research of neuropsychiatric diseases using rodent disease models. The long-term objective is to catalyze the discovery of new ther ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE)

    SBC: POSIT SCIENCE CORP            Topic: NIA

    PROJECT ABSTRACT Advancing age is often accompanied by a decline of key neuromodulatory centers of the brain that support adaptive neuroplasticity. Deterioration of the underlying neurophysiology of the brain predisposes the individual to pathological and age-related cognitive decline. We propose to deploy a computerized cognitive training program (INHANCE) developed via two successful SBIR-funded ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Next generation in vivo miniature microscopes integrating dual-color imaging, 3D imaging, and optogenetic stimulation with a cloud-compatible data acquisition platform

    SBC: Inscopix, Inc.            Topic: 101

    Project Summary Our understanding of neuropsychiatric disorders is undergoing a paradigm shift away from simple models emphasizing neurotransmitter imbalance towards more sophisticated theories based on abnormalities in neural circuit function. This is especially important for understanding disorders like Schizophrenia and PTSD, which defy simple biochemical explanations, but are now known to invo ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Trans Women Connected: a mobile app delivered sexual health promotion program

    SBC: DFUSION INC.            Topic: 102

    ABSTRACT: , Trans Women Connected: a mobile app delivered sexual health promotion program During the past two decades, the HIV epidemic has severely impacted transgender women in the U.S. According to the CDC persons have the highest HIV incidence of any risk group (56% of Black transgender women are living with HIV), and discrepancies between self-reported prevalence and HIV testing data indicate ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Iridium-electrode inhaled Nitric Oxide generator for treatment of hypoxic respiratory failure in neonates

    SBC: Third Pole, Inc.            Topic: NHLBI

    ABSTRACT Funding is requested to support essential steps required to commercialize 3P-001, a medical device thatgenerates medical grade nitric oxide (NO) from air. NO is a pulmonary vasodilator to treat hypoxic respiratoryfailure (HRF) in neonates (blue babies) and pulmonary hypertension in patients having cardiothoracic surgery (CTS). Third Pole’s value proposition is that availability of a tan ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. BurntOut: Role-Play Simulation for Building Medical Student Resiliency

    SBC: Clinical Tools, Inc            Topic: 400

    PROJECT DESCRIPTIONBurntOut: Role-Play Simulation for Building Medical Student Resiliency Medical student and physician burnout rates are high. Rates correlate with alcohol and other substance use problems, and negatively impact patient care. This project will create a 3D simulation BurntOut: Role- Play Simulation for medical students to practice and respond to stressful situations, enhance coping ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Assessment of Multiple Dose Administration ofGlucagon Receptor Blocker REMD477 in Type 1 Diabetes

    SBC: REMD BIOTHERAPEUTICS INC.            Topic: 200

    ABSTRACT Insulin remains the mainstay treatment for type 1 diabetes mellitus (T1D); however, it is associated with chronic iatrogenic hyperinsulinemia and life-threatening hypoglycemia events. Long term insulin treatment is also associated with secondary hyperlipidemia, and a higher incidence of cardiovascular complications, which tend to be more severe. Indeed, death due to cardiovascular complic ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Advancing a novel potent double anti-HCV nucleoside analog combination treatment for the OUD population to the clinic

    SBC: Riboscience LLC            Topic: NIDA

    Our goal is to develop an ultra short curative regimen for hepatitis C virus (HCV) infection in OUD patients. HCV is a major co-morbidity of many OUD patients. Treating their HCV reduces their subsequent IV drug use. While currently available regimens can cure HCV in most patients in 8-12 weeks, longer in patients with advanced liver disease or drug resistance mutations that are more frequent in O ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Practical Implementation of an Ultra-rapid FLASH Radiation Therapy Linac Beamline

    SBC: TIBARAY, INC.            Topic: 101

    PROJECT SUMMARY/ABSTRACT The mission of TibaRay, Inc. is to develop and clinically translate next-generation radiation therapy technologies for the treatment of cancer, the single leading cause of death worldwide and increasing epidemically. A major advance in radiation therapy (RT) that has increased its curative potential and decreased side effects is the ability to sculpt radiation doses exquis ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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