Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Stable Glucagon for Treatment of Hyperinsulinism

    SBC: AMIDEBIO, LLC            Topic: 200

    In severe persistent hyperinsulinismHIrepeated hypoglycemic episodes can ultimately lead to permanent seizure disorderslearning disabilitiescerebral palsyblindness and even deathClinical studies have demonstrated the effectiveness of both short term and long term treatment with glucagon for severe forms of HI and continuous subcutaneous administration of glucagon has been recommended both because ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Serious Games and Physical Activities Instructed by a Social Robot for Improving the Well-being of Elderly Individuals with Alzheimer's Disease and Dementia

    SBC: Dream Face Technologies, LLC            Topic: NIA

    The objective of the proposed direct Phase II SBIR project is to develop and study and the effectiveness of Serious Games and physical Activities played performed by elderly people with Alzheimer s disease and ADrelated Dementias in interaction with Ryanour successfully piloted Socially Assistive RobotSARRyan is an intelligent conversational life like social robotdesigned to improve the well being ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Quality Control Program for Quantitative MRI DataAcquisition and Analysis in Multi-site Clinical Trials

    SBC: QalibreMD, Inc.            Topic: 101

    Project Summary Abstract There has been a shift to greater use of neadjuvant chemotherapyNACTin the clinical management of cancerOften used in breast cancer to provide systemic treatment for possible or apparent metastatic diseaseNACT also reduces the primary tumor size and facilitates breast conservationQuantitative magnetic resonance imagingqMRIis an effective diagnostic for monitoring tumor reg ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. C.A.R.E.S.: A Mobile Health Program for Alcohol Risk Reduction for an Under-Served College Population

    SBC: Live Inspired, LLC            Topic: 550

    Excessive alcohol use is the third leading preventable cause of death in the U Swith young adults agesshowing the highest rates of hazardous alcohol useCommunity colleges serve overmillion studentscomprisingof all U Scollege studentsCommunity college studentsCCSshow rates of heavy alcohol use similar to students at traditional four year residentialFYRcollegesbut CCS are at higher risk for negative ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: IsoPlexis            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of Ryan Companion Robot for Assisting Elderly People with Alzheimer's Disease

    SBC: Dream Face Technologies, LLC            Topic: NIA

    The objective of the proposed Fast Track SBIR effort is to develop and commercialize the Ryan CompanionBothereafterRyanan intelligent conversational life like social robotdesigned to improve the well being and quality of life of older adults with early stage Alzheimerandapos s diseaseADand AD Related DementiaADRDAccording to the NIAresearch reports estimate that as many asmillion Americans may hav ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Synoptic Approach to Harmonize Discrete Data Streams in Application Development

    SBC: It Works Inc            Topic: 180NH1

    Research conducted in Phase I identified a range of data sources providing vehicle related information to consumers shopping around or interested in knowing more about vehicles. Majority of the commercial data sources focused on vehicle features, new/used/CPO pricing, and vehicles listings. Such data sources lacked safety as their central focus, which is a concern for U.S. Department of Transporta ...

    SBIR Phase II 2019 Department of Transportation
  8. A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies

    SBC: IsoPlexis            Topic: NCI

    While CAR T therapies have advanced in the clinicthere are still two specific issues using these breakthrough therapies for blood cancersDurable responses in patients are only atand Cytokine Release Syndrome occurs inof treated patientsThese limitationsfor a drug that costs as much as $may cost an additional $for treating adverse events leading to caution for many clinical centers to administer th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation

    SBC: IsoPlexis            Topic: 102

    IsoPlexis proposes to deliver a novel multi omic method for targeted profiling of both the TCR sequence and proteome from an array ofsingle cellsSpecificallywe will deliver a single cellTCR sequencing and protein capture assay for identifying responsive antigen specific TCRsand concurrently evaluate these T cells for functional response to that antigenThe challenge remains to link the activation o ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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