Award Data

In severe persistent hyperinsulinism (HI), repeated hypoglycemic episodes can ultimately lead to permanent seizure disorders, learning disabilities, cerebral palsy, blindness and even death. Clinical studies have demonstrated the effectiveness of both short-term and long-term treatment with glucagon for severe forms of HI and continuous subcutaneous administration of glucagon has been recommended ...

The objective of the proposed direct Phase-II SBIR project is to develop and study and the effectiveness of Serious Games and physical Activities played/performed by elderly people with Alzheimer’s disease and AD- related Dementias in interaction with Ryan, our successfully piloted Socially Assistive Robot (SAR). Ryan is an intelligent conversational life-like social robot, designed to improve t ...

Project Summary/Abstract There has been a shift to greater use of neadjuvant chemotherapy (NACT) in the clinical management of cancer. Often used in breast cancer to provide systemic treatment for possible or apparent metastatic disease, NACT also reduces the primary tumor size and facilitates breast conservation. Quantitative magnetic resonance imaging (qMRI) is an effective diagnostic for monito ...

Excessive alcohol use is the third-leading preventable cause of death in the U.S. with young adults ages 18-29 showing the highest rates of hazardous alcohol use. Community colleges serve over 12 million students, comprising 45% of all U.S. college students. Community college students (CCS) show rates of heavy alcohol use similar to students at traditional four-year residential (FYR) colleges, but ...

Although signal transduction inhibitors occasionally offer clinical benefit for cancer patients, signal flux emanating from oncogenes is often distributed through multiple pathways, potentially underlying the resistance which causes failure of most such inhibitors. Measuring signal flux through multiple pathways, in response to signal transduction inhibitors, may help uncover network inter- action ...

The objective of the proposed Fast-Track SBIR effort is to develop and commercialize the Ryan CompanionBot (hereafter, Ryan), an intelligent conversational life-like social robot, designed to improve the well-being and quality of life of older adults with early stage Alzheimerandapos;s disease (AD) and AD-Related Dementia (ADRD). According to the NIA, research reports estimate that as many as 5.1 ...

Research conducted in Phase I identified a range of data sources providing vehicle related information to consumers shopping around or interested in knowing more about vehicles. Majority of the commercial data sources focused on vehicle features, new/used/CPO pricing, and vehicles listings. Such data sources lacked safety as their central focus, which is a concern for U.S. Department of Transporta ...

While CAR-T therapies have advanced in the clinic, there are still two specific issues using these breakthrough therapies for blood cancers: Durable responses in patients are only at 30-50% and Cytokine Release Syndrome occurs in 60-90% of treated patients. These limitations, for a drug that costs as much as $500,000, may cost an additional $250,000+ for treating adverse events leading to caution ...

Hypervelocity projectiles (HVPs) offer the potential for highly effective and low-cost point defense against missile threats. Classical guidance schemes are ill-suited to the unpowered dynamics of the HVP, as they fail to account for its changing capabilities and limited energy budget over the course of the fly-out. Numerica’s solution consists of an automated real-time fly-out trajectory optimi ...

IsoPlexis proposes to deliver a novel multi-omic method for targeted profiling of both the TCR sequence and proteome from an array of 1000+ single cells. Specifically, we will deliver a single-cell, TCR sequencing and protein capture assay for identifying responsive antigen specific TCRs, and concurrently evaluate these T-cells for functional response to that antigen. The challenge remains to link ...