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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Stable Glucagon for Treatment of Hyperinsulinism

    SBC: AMIDEBIO, LLC            Topic: 200

    In severe persistent hyperinsulinism (HI), repeated hypoglycemic episodes can ultimately lead to permanent seizure disorders, learning disabilities, cerebral palsy, blindness and even death. Clinical studies have demonstrated the effectiveness of both short-term and long-term treatment with glucagon for severe forms of HI and continuous subcutaneous administration of glucagon has been recommended ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Serious Games and Physical Activities Instructed by a Social Robot for Improving the Well-being of Elderly Individuals with Alzheimer's Disease and Dementia

    SBC: Dream Face Technologies, LLC            Topic: NIA

    The objective of the proposed direct Phase-II SBIR project is to develop and study and the effectiveness of Serious Games and physical Activities played/performed by elderly people with Alzheimer’s disease and AD- related Dementias in interaction with Ryan, our successfully piloted Socially Assistive Robot (SAR). Ryan is an intelligent conversational life-like social robot, designed to improve t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Quality Control Program for Quantitative MRI DataAcquisition and Analysis in Multi-site Clinical Trials

    SBC: CaliberMRI, Inc.            Topic: 101

    Project Summary/Abstract There has been a shift to greater use of neadjuvant chemotherapy (NACT) in the clinical management of cancer. Often used in breast cancer to provide systemic treatment for possible or apparent metastatic disease, NACT also reduces the primary tumor size and facilitates breast conservation. Quantitative magnetic resonance imaging (qMRI) is an effective diagnostic for monito ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. C.A.R.E.S.: A Mobile Health Program for Alcohol Risk Reduction for an Under-Served College Population

    SBC: Live Inspired, LLC            Topic: 550

    Excessive alcohol use is the third-leading preventable cause of death in the U.S. with young adults ages 18-29 showing the highest rates of hazardous alcohol use. Community colleges serve over 12 million students, comprising 45% of all U.S. college students. Community college students (CCS) show rates of heavy alcohol use similar to students at traditional four-year residential (FYR) colleges, but ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: IsoPlexis            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patients, signal flux emanating from oncogenes is often distributed through multiple pathways, potentially underlying the resistance which causes failure of most such inhibitors. Measuring signal flux through multiple pathways, in response to signal transduction inhibitors, may help uncover network inter- action ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of Ryan Companion Robot for Assisting Elderly People with Alzheimer's Disease

    SBC: Dream Face Technologies, LLC            Topic: NIA

    The objective of the proposed Fast-Track SBIR effort is to develop and commercialize the Ryan CompanionBot (hereafter, Ryan), an intelligent conversational life-like social robot, designed to improve the well-being and quality of life of older adults with early stage Alzheimerandapos;s disease (AD) and AD-Related Dementia (ADRD). According to the NIA, research reports estimate that as many as 5.1 ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Synoptic Approach to Harmonize Discrete Data Streams in Application Development

    SBC: It Works Inc            Topic: 180NH1

    Research conducted in Phase I identified a range of data sources providing vehicle related information to consumers shopping around or interested in knowing more about vehicles. Majority of the commercial data sources focused on vehicle features, new/used/CPO pricing, and vehicles listings. Such data sources lacked safety as their central focus, which is a concern for U.S. Department of Transporta ...

    SBIR Phase II 2019 Department of Transportation
  8. A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies

    SBC: IsoPlexis            Topic: 102

    While CAR-T therapies have advanced in the clinic, there are still two specific issues using these breakthrough therapies for blood cancers: Durable responses in patients are only at 30-50% and Cytokine Release Syndrome occurs in 60-90% of treated patients. These limitations, for a drug that costs as much as $500,000, may cost an additional $250,000+ for treating adverse events leading to caution ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation

    SBC: IsoPlexis            Topic: 102

    IsoPlexis proposes to deliver a novel multi-omic method for targeted profiling of both the TCR sequence and proteome from an array of 1000+ single cells. Specifically, we will deliver a single-cell, TCR sequencing and protein capture assay for identifying responsive antigen specific TCRs, and concurrently evaluate these T-cells for functional response to that antigen. The challenge remains to link ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point-of-care test that assesses the risk of neonatal sepsis (NS) and/or necrotizing enterocolitis (NEC) in infants based on Inter-alpha inhibitor proteins (IAIP) levels in blood. The test is expected to be simple, user-friendly, portable and suitable for use in the NICU. NS and NEC are associated with high mortality and morbidity, i ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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