Award Data

Project Summary/Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line-associated bloodstream infections (CLABSI), an important healthcare-associated infection. CLABSIs cost the US healthcare system approximately $2.3 billion annually (Pronovost, NEJM, 2009). Additionally, CLABSIs can be life threatening, especially in the very youn ...

The product to be delivered based on this innovation is a neutron scattering sample environment that enables efficient neutron scattering measurements of biopolymer solutions at high pressure. The proposed high-throughput, high-pressure small-angle neutron scattering (HTHP-SANS) sample environment addresses key customer needs and provides substantial advantages to both the scientific user ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to improve emergency clinical care. Emergency Departments are facing complex nursing utilization problems, fueled in part by scheduling systems built on flawed assumptions. Escalating nursing shortages and burnout must be addressed as fatigue is rampant. With hospitals facing significant r ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to improve clinical care for scoliosis patients. Scoliosis, a sideways curvature of the spine, affects 6-9 million individuals in the US, or 2-3% of the population, and has estimated healthcare costs of $3.5 billion by 2028. Current treatments for scoliosis include bracing and/or spinal su ...

At Caliola, we built OverKey to radically simplify the deployment of high-assurance encryption in austere environments. OverKey is a patent-pending distributed Virtual Private Network that enables secure, collaborative communications in Internet of Things

Phytodetectors will design and engineer a synthetic biological pump circuit to increase the volume of water produced via photosynthetic desalination. This project builds off previous technology designed by Phytodetectors: a mangrove-inspired ultra-filter that allows plants to purify salt water as well as secrete water with properties comparable to bottled water. The partnership seeks to demonstrat ...

Abstract PROJECT SUMMARY/ABSTRACT The recent groundbreaking experiment using a single neutralizing monoclonal antibody (nmAb) to reduce the death rate in Ebola virus (EBOV)-infected individuals highlights the importance of this class of drug in the treatment of infectious disease. In August 2019, Dr. Anthony Fauci announced that administration of mAb114 had reduced the death rate from 70% to appro ...

Caliola Engineering proposes to develop and demonstrate an affordable and rapidly deployable failover for Emergency Action Message (EAM) delivery. Our Emergency Aerostat Mesh Network (EAMNet) includes approximately 30 aerostats that can be launched on demand. This network will connect critical NC3 nodes at Malmstrom, F. E. Warren, Minot, and Offutt Air Force Bases (AFB) via a secure, redundant mes ...

Air Force Nuclear Weapons center requires Digital Engineering needs to connect critical data and programs to execute accelerated engineering pathways.  Even with modern digital tooling such as Cameo, IBM Rational Doors, AFSim and many others, it can still be hard to effectively collaborate on projects in the earliest stages of design considering the large number of stakeholders and challenges of ...

Carbon fiber based composited have enabled advanced aircrafts such as Boeing 787 and Airbus A350 wherein the fuel efficiency has improved by more than 10% by reducing the weight. The commercial carbon fibers have a density of 1.75-1.93 g/cc. There exists an opportunity to further reduce the weight of composites based on carbon fibers. During our past research and phase I work, we have demonstrated ...