Award Data

The United States has a vast network of pipelines used for fuel transport. This infrastructure, installed in 1950–1970, is one of the largest in the world. Yet poor/missing records of the materials used, combined with the overall age and associated environmental degradation effects, often results in unsafe operation. Current non-destructive inspection techniques are only capable of detecting mat ...

Research conducted in Phase I identified a range of data sources providing vehicle related information to consumers shopping around or interested in knowing more about vehicles. Majority of the commercial data sources focused on vehicle features, new/used/CPO pricing, and vehicles listings. Such data sources lacked safety as their central focus, which is a concern for U.S. Department of Transporta ...

High throughput screeningHTShas emerged as a leading method of drug discovery and development in the pharmaceutical industryacademiaand at the NIH National Center for Advancing Translational SciencesNCATSHTS relies on the ability to rapidly screen tens of thousands of compounds to identify the most promising drugs and their dose response curvesHTS isof necessityhighly automated and demands mechani ...

Cognitive decline is a major quality of life concern for many cancer survivorsThevarious available treatments affect individuals differentlyand research has unfortunately provided little guidance on how specific treatments impact neurocognitive functionTo help researchers fill this information gap and ultimately provide guidance to doctors and patientsa neuropsychological assessment system that is ...

Project Summary Systemic sclerosis (SSc) is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs, vascular dropout and autoantibody formation. SSc has the highest case fatality rate of any systemic autoimmune disease and there remain no FDA-approved therapies. Our data and that of others indicate that the innate immune system is the major driver of fibr ...

Abstract Optical Cherenkov video imaging of body anatomy and dose delivery can be used now to map out radiotherapy beam incidence upon the patient tissue, directly visualizing the radiation dose deposition on the patient in real time. This could serve as a non-contact workflow tool for verification for daily fractionated radiation therapy, allowing capture of all treatments, all the time. DoseOpti ...

The primary goal of this proposed research is to develop a rapid point-of-care test that assesses the risk of neonatal sepsis (NS) and/or necrotizing enterocolitis (NEC) in infants based on Inter-alpha inhibitor proteins (IAIP) levels in blood. The test is expected to be simple, user-friendly, portable and suitable for use in the NICU. NS and NEC are associated with high mortality and morbidity, i ...

PROJECT SUMMARY/ABSTRACT:CairnSurgical, Inc., a Dartmouth spin-off company, will standardize supine breast MRI to streamline pro- duction of the Breast Cancer Locator (BCL) as a cancer localization device for use in breast conserving surgery (BCS) to (i) eliminate wire localization – a moderately effective, somewhat costly and certainly inconvenient procedure for patients and surgeons – and co ...

PROJECT SUMMARY/ABSTRACT Creare and its clinical and research partners propose to develop a software platform, OnTRACK (Online Treatment Recovery Assistance for Concussion in Kids), for children and adolescents recovering from concussion or mild traumatic brain injury (mTBI). The platform includes a mobile application (app) for the patients and their care team (parents, teachers, coaches, etc.), a ...

Diode-Pumped Alkali Laser (DPAL) systems have great potential for missile defense and other applications. These systems require a uniform, steady, flowing mixture of helium and rubidium vapor at elevated pressure and temperature. Significant challenges exist because rubidium is a very reactive material. Our team has developed a contamination-free, hermetic circulator based on gas-bearing turbomach ...