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DNA HYBRIDIZATION PROBES SPECIFIC FOR COMMON PATHOGENIC BACTERIA HAVE BEEN DEVELOPED. THE LONG TERM OBJECTIVE OF THIS RESEARCH IS THE PERFECTION OF SIMPLE PROTOCOLS AND A KIT USING DNA HYBRIDIZATION PROBES FOR THE DETECTION AND IDENTIFICATION OF PATHOGENS IN CLINICAL SPECIMENS. THE SPECIFIC AIM OF THIS PROPOSAL IS TO ASSESS THE FEASABILITY OF THIS APPROACH TO PATHOGEN IDENTIFICATION IN CLINICAL SP ...

QUALITATIVE ADVANCES IN COMPUTER TECHNOLOGY HAVE LEVELED OFF SUFFICIENTLY TO JUSTIFY THE DEVELOPMENT OF A MULTI-USER, MULTI-FUNCTION, COMPREHENSIVE VISUAL TESTING INSTRUMENT FOR OPHTHALMOLOGISTS, VISUAL SCIENTISTS, AND OPTOMETRISTS. SUCH A SYSTEM COULD BE DEVELOPED WITH RELATIVE EASE WERE IT NOT FOR THE INDUSTRY STANDARD REFRESH RATE FOR GENERATING VIDEO IMAGES. UNFORTUNATELY, 60 HZ IS TOO SLOW FO ...

THIS PROPOSAL CONCERNS DEVELOPMENT OF AN INTERACTIVE, MICROCOMPUTER/VIDEODISC TOOL FOR TEACHING LIFE SKILLS TO LEARNING DISABLED HIGH SCHOOL STUDENTS. WE HAVE TERMED IT A LIFE SKILLS SYSTEM (LSS), AN ATTEMPT TO REMEDY PRESENT DAY SECONDARY SCHOOL CURRICULUM DEFICIENCIES IN TRAINING LD STUDENTS TO FUNCTION INDEPENDENTLY. THE LSS IS BASED ON FUNCTIONAL CONTEXT TRAINING, AND THUS IS A DISTINCT DEPART ...

THE PURPOSE OF THIS STUDY IS THREEFOLD: PART I WILL LAST APPROXIMATELY THREE MONTHS; THE GOAL OF THIS SEGMENT WILL BE TO DEVELOP ALL COMPONENTS REQUIRED FOR A SELF-MANAGEMENT PROGRAM FOR ALL ASTHMATIC PATIENTS. THIS WILL ENTAIL, IN PART, REFINING AND VIDEOTAPING PORTIONS OF A PROGRAM WITH PROVEN EFFICIENCY, WHEEZERS ANONYMOUS. IN ADDITION, RELIABILITY AND VALIDITY OF PAPER-AND-PENCIL INSTRUMENTS U ...

THE DEVELOPMENT OF HUMAN TUMOR COLONY FORMING ASSAYS (HTCFA) HAS OPENED NEW POSSIBILITIES FOR BASIC AND CLINICAL CANCER RESEARCH. HOWEVER, THE PERFORMANCE OF THE DOUBLE-LAYER AGAR TECHNIQUE CURRENTLY USED BY THE MAJORITY OF INVESTIGATORS HAS BEEN GENERALLY LOW. IN THIS CONTRACT, WE PROPOSE THE FURTHER DEVELOPMENT OF AN ALTERNATIVE TECHNIQUE OF TUMOR CELL CLONING USING GLASS CAPILLARY TUBES INSTEAD ...

AMONG THE MAJOR DOSE-LIMITING TOXICITIES OF CURRENTLY USED ANTICANCER DRUGS ARE THOSE AFFECTING THE BONE MARROW, CARDIOVASCULAR SYSTEM, LUNGS, GASTROINTESTINAL TRACT AND THE NERVOUS SYSTEM. HOWEVER, HEMATOTOXICITIES CONSTITUTE THE MOST COMMON AND OFTEN MOST SIGNIFICANT SIDE EFFECT OF THE MAJORITY OF AGENTS. WE PROPOSE THE FURTHER DEVELOPMENT AND CHARACTERIZATION OF IN VITRO SYSTEMS FOR HUMAN MYELO ...

ADVANCES IN MEDICAL CARE HAVE ALLOWED A GREATER NUMBER OF NEONATES TO SURVIVE. THE RESULT HAS BEEN AN INCREASE IN THE NUMBER OF INFANTS AT RISK FOR LATER INTELLECTUAL RETARDATION. HAPPILY, 80 TO 90% OF HIGH-RISK INFANTS ARE INTELLECTUALLY NORMAL LATER IN LIFE. UNFORTUNATELY, NO VALID SCREENING DEVICE FOR DIFFERENTIATING INFANTS WHO WILL LATER BE INTELLECTUALLY NORMAL FROM THOSE WHO WILL BE RETARDE ...

THE SPECIFIC AIM OF THIS PROJECT IS TO DEVELOP TECHNOLOGIC- ALLY EFFICIENT AND COST-EFFECTIVE METHODS FOR THE SEPARATIONAND PURIFICATION OF MULTIGRAM QUANTITIES OF HIGH POLYUN- SATURATES (E.G., EICOSAPNOIC ACID, EPA, C20:5W3; DOCOSAHEXAENOIC ACID, DHA, C22:6W3; AND ESTERS) FROM MARINE/FISH OILS, WITH THE LONG-TERM OBJECTIVE OF MAKING THESE AND POSSIBLY OTHER HIGH POLYUNSATURATES AVAILABLE FOR A WA ...

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DESIGN A SERUM-FREE CHEMICALLY DEFINED MEDIUM FOR OPTIMUM GROWTH OF MAMMALIAN CELLS IN VITRO. THE SPECIFIC AIM OF THIS PROPOSAL IS TO SOLUBILIZE, BY MEANS OTHER THAN THE USE OF CARRIER PROTEINS, FATTY ACIDS, ALPHA-LIPOIC ACID, FAT-SOLUBLE VITAMINS, AND CHOLESTEROL IN AN EXISTENT SERUM-FREE MEDIUM, CHEE'S ESSENTIAL MEDIUM (CEM). BESIDES HORMONES, GROWTH ...

ACCESSORY APARTMENTS BENEFIT OLDER HOMEOWNERS. THEY CAN PROVIDE INCOME, SECURITY, COMPANIONSHIP, AND A SOURCE OF SERVICES IN RETURN FOR RENT REDUCTIONS. THEY ALSO CREATE INEXPENSIVE RENTAL HOUSING, AND, BECAUSE OF THE BENEFITS LISTED ABOVE, A MEANS TO HELP OLDER HOMEOWNERS AGE IN PLACE.IN CONTRAST, INSTALLATION OF ACCESSORY APARTMENTS IS RARELY SEEN AS A WAY FOR BUSINESS PEOPLE TO MAKE MONEY. AS A ...