Award Data

CURRENT MORPHOMETRY AND IMAGE ANALYSIS SYSTEMS CAN BE BROADLY DIVIDED INTO THOSE WHICH DISPLAY AN IMAGE AND REQUIRE THE USER TO TRACE THE POINTS OR LINES CONSIDERED SIGNIFICANT, AND THOSE WHICH APPLY COMPLEX ALGORITHMS TO LOCATE SIGNIFICANT OBJECTS AUTONOMOUSLY. WE SEE A NEED FOR AN INTERMEDIATE TYPE OF SYSTEM IN WHICH THE USER COULD RAPIDLY INDICATE THE APPROXIMATE LOCATION OF SIGNIFICANT OBJECTS ...

OUR EXPERIENCE AND EXPERTISE IN THE DEVELOPMENT OF EDUCATIONAL SOFTWARE WILL BE COMBINED WITH THAT OF EDUCATORS, PHYSICIANS, AND OTHER HEALTH SPECIALISTS TO DEVELOP MICROCOMPUTER EDUCATIONAL SOFTWARE UNDER THE TITLE MY GOOD HEALTH. MY GOOD HEALTH IS PLANNED AS A SERIES OF GAMES INTENDED TO STIMULATE SCHOOL CHILDREN IN THE PURSUIT OF A BETTER UNDERSTANDING OF HUMAN HEALTH, AND OF WHAT ACTION THEY C ...

THE NONINVASIVE ULTRASOUND IMAGING OF THE ADULT BRAIN THROUGH THE INTACT SKULL HAS HAD LIMITED SUCCESS DUE TO THE TRANSMISSION DISTORTION OF THE SKULL. THE FEASIBILITY OF MEASURING SCALP AND SKULL THICKNESS BY ECHO RANGING AND INTERFERENCE TECHNIQUES TO GENERATE A MODEL TO COMPENSATE FOR DISTORTION IS PROPOSED. ONCE THE THREE-DIMENSIONAL MODEL OF THE SKULL IS OBTAINED, RAY TRACING TECHNIQUES ARE U ...

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MANY COMMERCIAL DYES HAVE A BENZIDINE BASE. EVIDENCE SUGGESTS A CAUSAL RELATIONSHIP BETWEEN THESE DYES AND BLADDER CANCER IN HUMANS. ROUTINE SHORT-TERM TESTS ARE INEFFICIENT FOR DETECTION OF THE BENZIDINE BASE DYES WITHOUT MODIFICATIONS. SHORT-TERM TESTS COUPLED TO ACTIVATION SYSTEMS FROM RODENT CELLS OR FRACTIONS MAY NOT BE GERMANE FOR EXTRAPOLATION TO HUMAN RISK. RECOGNIZING A NEED FOR RELEVANT ...

COLORECTAL CARCINOMA IS ONE OF THE MOST PREVALENT AND LETHAL CANCERS IN THE UNITED STATES. ACCORDING TO THE AMERICAN CANCER SOCIETY, THERE ARE 130,000 NEW CASES EACH YEAR. EARLY DIAGNOSIS IS DIFFICULT AND THERE IS NO DIAGNOSTIC TEST WITH A HIGH POSITIVE PREDICTIVE VALUE IN THE EARLY STAGES OF THE DISEASE. DEVELOPMENT OF A TEST THAT DETECTS EARLY COLORECTAL CARCINOMA WOULD SIGNIFICANTLY REDUCE MORB ...

A STUDY IS PROPOSED WHICH WILL DETERMINE THE FEASIBILITY OF DEVELOPING A COMPUTER BASED MODEL FOR ADMINISTERING ASSESSMENT AND THERAPY TO MENTALLY RETARDED/DEVELOPMENTALLY DISABLED INFANTS AND CHILDREN. THE PRINCIPAL AIM OF PHASE I IS TO SURVEY CURRENT TECHNOLOGIES AS THEY RELATE TO THERAPY AND PROVIDE A BASIS FOR A PHASE II RESEARCH PLAN. HARDWARE AND SOFTWARE BASED SIMULATION OF A MODEL WILL BE ...

PRIMARY AROMATIC AMINES THAT WERE IMPLICATED IN BLADDER CARCINOGENESIS (BASED ON THE EPIDEMIOLOGICAL DATA WITH WORKERS IN RUBBER AND DYE INDUSTRIES) EXHIBIT SEX AND SPECIES SPECIFICITY. URINARY AND BLADDER CANCER IS MORE PREVALENT IN CAUCASIAN MALES. AROMATIC AMINES ARE MORE CARCINOGENIC IN DOGS AND LESS ACTIVE IN RODENTS, WHICH CORRELATES TO THE RELATIVE METABOLIC ACTIVITIES IN RESPECTIVE TISSUES ...

WE PROPOSE TO DEVELOP AND TEST A PORTABLE COMPUTER-BASED DATA COLLECTION/ANALYSIS AND COMPLIANCE ENHANCEMENT SYSTEM FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS (NIDDM). THE DIACARE SYSTEM II WILL CONSIST OF THE DIACARE MONITOR (HARDWARE), WHICH COMBINES COMPUTER CAPABILITIES OF A COMMERCIALLY AVAILABLE HAND-HELD COMPUTER WITH OUR OWN REFLECTANCE PHOTOMETER GLUCOSE ANALYSIS AND DAT ...

THE OVERALL GOAL OF THIS RESEARCH PROJECT IS TO DETERMINE THE FEASIBILITY OF USING CONTRAST AGENTS FOR NUCLEAR MAGNETIC RESONANCE (NMR) IMAGING. SPECIFICALLY, NITROXIDES OF VARYING STRUCTURE WILL BE SYNTHESIZED. EACH PROTOTYPE AGENT WILL BE STUDIED FROM A PHARMACOKINETIC, DISTRIBUTION, AND METABOLIC STANDPOINT. THOSE NITROXIDES WITH SUITABLE PROPERTIES WILL BE FURTHER INVESTIGATED FOR THEIR ABILIT ...