Award Data

Structural failure can be predicted by sensing ultrasonic acoustic emissions, spontaneously created when stress energy is released as metals fatigue due to a cyclic load. However, conventional piezoelectric sensors suffer rapid performance degradation when exposed to extreme temperatures and neutron radiation, limiting their ability to monitor the health of nuclear infrastructure. We will develop ...

SUMMARY Sepsis is a clinical syndrome that complicates severe infectionSepsis remains the leading cause of morbidity and mortality in critically ill patientsThere are no specific FDA approved medicines for the treatment of sepsisCurrent concepts of the pathophysiology of sepsis suggest that organ failure and mortality in sepsis are caused by inappropriate regulation of the immune systemThis manife ...

Over the past two decades, there has been a drastic advance in the sensing technologies and data acquisition systems. These technologies have been deployed in carbon sequestration to continuously monitor CO2 migration and location during and after injection. A complex network of surface and underground sensors is often installed generating large volume of intricate datasets. These datasets require ...

DESCRIPTION (provided by applicant): Our goal is to develop an efficient and inexpensive toolkit for ablating or reversibly inactivating specific cell types in the brain or other organs of mammals. We propose new techniques in which the genes for nitroreductase (NTR) or Drosophila allatostatin receptor (AlstR) are delivered into cells using an adeno-associated viral vector (AAV). Both are fusion ...

The term benchmark originates from the chiseled horizontal marks that surveyors made, into which an angle-iron could be placed to bracket ("bench") a leveling rod, thus ensuring that the leveling rod can be repositioned in exactly the same place in the future. A benchmark in computer terms is the result of running a computer program, or a set of programs, in order to assess the relative performanc ...

DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias, cardiopulmonary obstruction, progressive neurologic impairment and death by age 15. MPS I is currently treated b ...

Abstract Chemical exposure poses a threat to the safety and health of each of us, especially those who work in certain industries, such as petroleum extraction and refinery facilities, mining industry, and fertilizer factories. Various sensing technologies have been developed over the past decades to address the need, but a low cost and accurate personal exposure device that can track multiple che ...

Aerosol extinction measurements are crucial to understanding the effects of atmospheric particles on ozone depletion (stratosphere), radiation (stratosphere and troposphere), visibility (troposphere) and public health (boundary layer).nbsp; Despite the acute need, no existing instrument can measure direct, in situ aerosol extinction profiles from the ground to the mid-stratosphere.nbsp; Satellite- ...

THE BAYESIAN DIAGNOSTIC SYSTEM (BDS) IS PROPOSED AS THE CENTRAL INFERENCE ENGINE OF AN ARTIFICIAL INTELLIGENCE SYSTEM (EXPERT SYSTEM) FOR REACTOR PLANT CONTROL AND MAINTENANCE. THE EXPERT SYSTEM, COPILOT, IS ALREADY UNDER DEVELOPMENT AT PLG UNDER LIMITED IN-HOUSE FUNDING. THE EXISTING WORK INVOLVES DEVELOPMENT OF THE "DOMAIN KNOWLEDGE BASE" OF POWER PLANT SYSTEMS, PROCEDURES, AND ANALYSIS RESULTS ...

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