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Summary Abstract Chemotherapy induced peripheral neuropathyCIPNis detected inof cancer patients during all phases of cancerSensory symptoms in the hands and or feettypically in astocking glovepatternare commonand manifested as painnumbnessand or tinglingCIPN can result in chemotherapy dose reduction or discontinuationand can also have long term effects on the quality of lifeThe course of CIPN can ...

PROJECT SUMMARY With the exception of the Breathalyzer for alcoholthere is currently no available technology that can immediately identify neurologic impairment related to the use of licit or illicit drugsThe illicit use of opioids in particular currently represents a nation wide health crisiswith an estimatedmillion Americans misusing opioids inThe presently available methods for detecting opioid ...

ABSTRACT Chemotherapy induced peripheral neuropathyCIPNis a commonprevalenceand potentially doselimiting side effect of many cancer chemotherapy drug treatment regimensClinicallyCIPN presents with pain that is burningshooting or electric shock likeThe increase in prevalence of cancer coupled with an increase in the cancer survival rates due to chemotherapy regimens is transforming cancer pain into ...

PROJECT SUMMARYABSTRACTWith nearlymln people suffering from chronic pain in the US alone and the global market projected to reach $bln bythere is both a major unmet medical need and a significant commercial opportunityDominated by opioid drugsthis field also suffered from alarming consequences of opioid drug overuse and misuseAntagonists acting at TRPVreceptor have long been recognized as one of t ...

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PROJECT SUMMARY ABSTRACT Alzheimer s diseaseADis a progressive multifactorial disease affecting more thanmillion people worldwide and is the most common dementia of late lifeTo dateno interventions have demonstrated substantial therapeutic efficacy to preventdelay or treat ADCurrent thinking in the field embraces the complexity of AD pathophysiologywhich has enabled a more diverse therapeutic pipe ...

PROJECT SUMMARY ABSTRACT SignificanceCell therapy is expected to become an important method to treat chronic diseases such as diabetesrheumatoid arthritisretinal diseases like macular degeneration and certain types of cancersThe cell therapy market in general is projected to become a $billion industry byHuman pluripotent stem cellshPSCsare of particular importance since their utility as a source f ...

Abstract Immune checkpoint inhibitorICIimmunotherapeutics are having an important and expanding impact on the treatment of cancerAfter only a few years of clinical useICIs have become a multi billion dollar family of productsHoweveronlyof patients have a positive response to treatmentTo datethe best indicator for a positive response is the microsatellite instabilityMSIstatusIndividualsno matter wh ...

In response to Department of Defense SBIR topic N192-063, SBIR/STTR Phase I solicitation, Alphacore proposes to develop a low-cost, Multi-channel, High Resolution (HR), Wideband (WB) LIDAR Digitizer ASIC. The significance of this innovation is that the ASIC meets the critical needs for a high-resolution, wide-bandwidth readout solution, capable of large dynamic range with real-time processing. Nav ...

Visual Landing Aids on air capable ships and aircraft carrier flight decks are required for night and/or low visibility aircraft operations for general lighting, navigation, flight deck, and special purposes. Future aircraft are expected to have hotter exhaust that could threaten the integrity of these lighting fixtures. During Phase 1 and Phase 2, a new form fit functional converter assembly, wit ...