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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. STTR Phase I: The xAristotle Platform for Advanced X-ray Spectroscopy

    SBC: EASYXAFS LLC            Topic: IH

    The broader impact of this Small Business Technology Transfer (STTR) Phase I project takes several forms. The basic product enables new hands-on undergraduate instruction in advanced x-ray methods for use in development of electrical energy storage and catalysis systems. Next, upgraded versions of this product will open a new market for use of these x-ray methods in industrial quality control and ...

    STTR Phase I 2019 National Science Foundation
  2. Transforming smartphones into active sonar systems to detect opioid overdose

    SBC: Sound Life Sciences, Inc.            Topic: NIDA

    PROJECT SUMMARY ABSTRACT Opioid use disorderOUDand mortality from opioid overdose are significant public health concernsDeaths from opioid overdose are highly preventable with early detection and administration of naloxoneA key challenge of the epidemic is that overdose victims often die because they are alone or among untrained or impaired bystanders and thus do not receive timely resuscitationTh ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Organ-on-chip based assays for personalized assessment of renal resilience in aging patients

    SBC: Nortis, Inc.            Topic: NIA

    Project Summary Age related kidney diseasesincluding chronic kidney diseaseCKDand acute kidney injuryAKIare major health problems and an economic burden worldwideIn the U Salonemillion people are affected by CKD diseasealthough the vast majority of these individuals are unaware of their conditionA coexisting diseasea new medicationor a surgical procedure can overstress the already compromised kidn ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Connected Pharmacy Platform to Improve Adherence to Buprenorphine-Naloxone Prescription Treatment of Opioid Use Disorder

    SBC: Pillsy Inc.            Topic: NIDA

    Project Summary Abstract The United States is in the midst of an opioid epidemicInmost recent estimatesmillion people met diagnostic criteria for opioid use disorderOUDIn that same yearAmericans died of opioid overdose an average ofpreventable deaths per dayOpioid agonist therapyOATsuch as buprenorphine naloxoneBUP NALcan reduce opioid overdose deaths by at leastdecrease opioid misuseand improve q ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Direct Reprogramming of Human Fibroblasts into Functional Cardiomyocytes by Non-Integrating Cardiogenic Nanoparticles

    SBC: TATEVA THERAPEUTICS INC.            Topic: NHLBI

    Abstract Generation of human pluripotent stem cells upon reprogramming of patient-specific somatic cells and subsequent differentiation of the stem cells into more specialized cell types opened new exciting opportunities for human regenerative medicine. Direct reprogramming of fibroblasts to various cell types including neural cells and cardiomyocytes using different sets of bioactive factors was ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Automated Health Assessment through Mobile Sensing and Machine Learning of Daily Activities

    SBC: ADAPTELLIGENCE LLC            Topic: NIBIB

    PROJECT SUMMARY ABSTRACTAdvances in health care have been dramatic since the beginning of the millenniumAs a resultpeople are living longer with age related diseasesand the number of older individuals unable to live independently is rising rapidlyMobile computing offers an unprecedented opportunity to unobtrusively monitor behavior and use the large amount of collected data to automate analysis of ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Targeted lympho-ablation as an alternative to HSCT to cure T1D

    SBC: AVM BIOTECHNOLOGY LLC            Topic: 200

    With insulin being the only approved treatment of Typediabetes mellitusT DMthere is a very large unmet medical need for a definitive cure for pediatric and adult patientsIncrease in obesityunhealthy dietand physical inactivity are driving the prevalence of diabetes among all agesIn the U Sdiabetes currently affectsof the population of all agesand it is the seventh leading cause of deathwith an est ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. JOC-x: Chemotherapy conjugates that open tumor tight junctions to treat cancer

    SBC: PAI LIFE SCIENCES INC            Topic: 102

    PROJECT SUMMARY A central mechanism of tumor drug resistance is the maintenance of tight junctions between malignant cells preventing penetration of molecules into the tumor microenvironment. We have generated junction openers (“JO”) that are small proteins that bind to desmoglein 2 (DSG2), a junction protein that is overexpressed in many cancers. Intravenous injection of JO increases tumor pe ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. PIXUL-FFPE:High throughput platform for chromatin and DNA sample preparation from formalin fixed paraffin embedded (FFPE) tissue samples.

    SBC: MATCHSTICK TECHNOLOGIES INC            Topic: 172

    Formalin fixed paraffin embeddedFFPEtissue archives represent the largest clinically annotated human specimen repositoryThe estimated millions of available FFPE tissue samples provide vast resource for the discovery of disease epigenetic pathwaysbiomarkers and drug targetsAnd yetthese samples are highly underutilized because current methods for extracting molecular information from FFPE samples ar ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A Device to Inhibit Heterotopic Ossification

    SBC: IN SITU THERAPEUTIC SOLUTIONS, INC.            Topic: NIAMS

    PROJECT SUMMARY ABSTRACT Heterotopic ossificationHOis defined by bone formation in soft tissue and is a frequent debilitating complication of surgical procedures required by musculoskeletal and neurological injuriesUnfortunatelyit is not possible to accurately predict which patients will develop symptomatic HOwhich is characterized by pain and impaired functionThe current prophylactic standard of ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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