Award Data

Project Summary Abstract TITLEPERCUTANEOUS TREATMENT OF PERIPHERAL ARTERIAL OCCLUSIVE DISEASE WITH IMPLANTATION OF SERIALBALLOON EXPANDABLEPACLITAXEL ELUTING RESORBABLE SCAFFOLDSthe Efemoral DeviceAbstract Peripheral Arterial Occlusive DiseasePAODalso known as Peripheral Vascular Diseasepoor circulationorhardening of the arteriesis a worldwide plagueSymptomatic PAOD affects approximatelyof the pop ...

Project Summary Stroke is the 5th leading cause of death and number one cause of adult disability in the United States. The primary goal of acute ischemic stroke (AIS) treatment is quickly restoring blood perfusion. However, studies have shown that this return of blood flow, while necessary, can also cause damage to local tissue leading to poor patient outcomes. Therapeutic hypothermia (TH) has be ...

SUMMARY: The White House has initiated an aggressive campaign to combat the current opioid crisis that is affecting all levels of the American way of life. The opioid crisis has emerged from multiple fronts. Among these various fronts, the continued use of opioids in the post-operative area is a growing addiction risk. Current post- operative pain management utilizes a multimodal pain management s ...

Project SummaryThere is an enormous need for the development of a new class of neurotransmitterNTsensors that are versatileselectivesensitive and reliable to allow investigation of the neurobiological mechanisms of behavior and disease symptomsThis STTR proposal will focus on implementing a novel microarray probe for in vivoreal time sensing of glutamateGLUand gamma aminobutyric acidGABAGLU and GA ...

ABSTRACT More thanmillion women suffer from pelvic health disordersPHDsin the United Statesa number that is projected to nearly double byThese conditions cost the healthcare system billions annually and negatively affect educational and employment opportunitiesquality of lifeand fertility of patientsWhile studies suggest that PHDs can be managed and improved with educationpractitioners are often c ...

Injury to joints can lead to painful defects in articular cartilage and the underlying bone, which adversely affect the function and biological health of the entire joint. Current solutions for cartilage (chondral) and cartilage-and- bone (osteochondral) defects, are unreliable, are technically challenging, and often require multiple procedures. A surgeon-engineer-biologist team at Hospital for Sp ...

PROJECT SUMMARY Osteoarthritis is today a major worldwide challenge for health systemsrepresenting the most common degenerative joint disorder and the leading cause of chronic disability among older adultsIn the U SaloneOA affectsmillion people and it represents a $billion economic burdenAvailable pharmacological treatments only provide symptomatic pain relief and fail to arrest the progressive de ...

SummaryThird generationlong read sequencing technologies are increasingly sought after for the analysis of difficult genomic regionssuch as the major histocompatibility complexMHCthe human leukocyte antigenHLAloci and genomes of cancerspathogens and viral insertionsas well as plant and animal genomesSuch methods provide researchers with more contextual informationenabling analysis of highly comple ...

Specific AimValidate the MORLinkLight assay with a pilot HTS to identify molecules modulating MOR traffickingSignificanceThe current crisis of opioid use disordersOUDsand opioid overdose deaths in the United States urgently demands safer and better therapeuticsTo develop better and safer therapeutic agents for the treatment of OUDsfirst and foremost is to have new bioassays which are different fro ...

PROJECT SUMMARY ObjectivesTo develop a computer based cognitive training system for breast cancer survivors who are suffering from cognitive impairments subsequent to chemotherapyA home based system will be developedtargeting executive functionsattention and memory cognitive domainsThe system will incorporate a novel low cost biosensor deviceSpecific AimsDevelopmentvalidation and usability evaluat ...