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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. NET- Selective Ligands for the Treatment of Depression

    SBC: Acenta Discovery, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): World-wide public health surveys point to an increased global health burden for serious psychiatric disorders, particularly depression. Indeed, by 2020 it is expected that depression may be the second most serious medical condition with respect to global disease burden. It is clear that more effective pharmacotherapies are needed in treating depressive illn ...

    STTR Phase I 2003 Department of Health and Human Services
  2. Genetic Assay for Inhibitors of RNA-Protein Interactions

    SBC: ADVANCED GENETIC SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses, including HIV, hepatitis C, and West Nile virus, and thus represent attractive targets for therapeutics. Much of our previous work has centered on identifying and characterizing the components of key interactions and developing cell-b ...

    STTR Phase I 2003 Department of Health and Human Services
  3. Personalizing Speech Output for Communication Devices

    SBC: AGORA NET INC            Topic: N/A

    DESCRIPTION (provided by applicant): ModelTalker is a text-to-speech synthesis (TTS) system intended to be of particular interest to potential Augmentative and Alternative Communication (AAC) device users. Most present AAC devices use TTS software that derives from rule-based formant synthesis algorithms developed in the 1970s, but modern concatenative synthesis systems (of which ModelTalker is an ...

    STTR Phase I 2003 Department of Health and Human Services
  4. Hydronic, High-Speed, Focal Thermal Stimulator

    SBC: ALA SCIENTIFIC INSTRUMENTS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Cloning of the hot and cold thermal receptors has advanced the understanding of the molecular basis of thermal sensation. Two important remaining questions to be addressed are the identification of additional thermal receptor genes and the elucidation of the mechanism(s) that enable the receptor proteins to alter gating properties in response to changes in temp ...

    STTR Phase I 2003 Department of Health and Human Services
  5. Night Alert Prompting System

    SBC: AMRON CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term aim of this program of research is to develop a Night Alert Prompting System (NAPS) that can be used by caregivers of home-dwelling cognitively impaired (CI) individuals to prevent nighttime injuries and unattended exits, improve caregiver sleep, reduce caregiver worry, and thereby delay institutionalization of the CI individuals. The primary func ...

    STTR Phase I 2003 Department of Health and Human Services
  6. Night Alert Prompting System

    SBC: AMRON CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term aim of this program of research is to develop a Night Alert Prompting System (NAPS) that can be used by caregivers of home-dwelling cognitively impaired (CI) individuals to prevent nighttime injuries and unattended exits, improve caregiver sleep, reduce caregiver worry, and thereby delay institutionalization of the CI individuals. The primary func ...

    STTR Phase II 2003 Department of Health and Human Services
  7. Peptide Transduction-based Therapies for CF

    SBC: Ansata Therapeutics, Inc.            Topic: N/A

    DESCRIPTION: (provided by applicant): Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding CFTR that results in a significantly shorter lifespan as well as associated pathologies. Unfortunately, none of the currently available treatments are able to halt the progression of the disease. The predominant CFTR mutation, deltaF508, results in a mutant protein that is retai ...

    STTR Phase I 2003 Department of Health and Human Services
  8. Ultraviolet Light Devices for Vitamin D

    SBC: APOLLO LIGHT SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Vitamin D deficiency is now recognized as a significant health problem for middle-aged and older adults. Vitamin D deficiency exacerbates osteoporosis and causes the bone disease, osteomalacia. Vitamin D deficiency increases risk of skeletal fractures. It is well known that the ultraviolet B portion of the solar spectrum is responsible for the cutaneous product ...

    STTR Phase I 2003 Department of Health and Human Services
  9. Anti Inflammatory Membranes for Implantable Biosensors

    SBC: APPLIED TISSUE AND MATERIALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The prolonged inflammatory response to an implant is one of the primary causes for the failure to integrate implanted devices into tissue. The source of inflammation common to almost all implants is the foreign body response. Based on evidence in the literature and from our research team, the inflammatory response is mediated by the reactive oxygen species gene ...

    STTR Phase I 2003 Department of Health and Human Services
  10. Gene Expression and Diagnosis of Autoimmune Disease

    SBC: ARTHROCHIP, LLC            Topic: N/A

    DESCRIPTION (provided by the applicant): Autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes, and multiple sclerosis, are thought to arise from abnormalities of innate or adaptive immune responses. Autoimmune diseases are often difficult to diagnose, as the symptoms can be typical of other conditions and quite vague, such as musculoskeletal complaints ...

    STTR Phase I 2003 Department of Health and Human Services

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