Award Data

THE GOAL OF THIS RESEARCH IS TO DETERMINE THE FEASIBILITY OF COMBINING THREE-CHANNEL RECORDING OF THE AUDITORY BRAINSTEM RESPONSE (ABR) WITH A STIMULUS-PAIRS TECHNIQUE SO AS TO MEASURE THE DECREMENT IN RESPONSE THAT OCCURS IN THE RELATIVE REFRACTORY PERIOD (RRP). THIS METHOD WILL PERMIT DETECTION OF ANY ABNORMALITIES THAT AFFECT THE RRP, AS THE PARAMETERS CAN BE ADJUSTED SO THAT THERE IS DECREMENT ...

THE LONG-RANGE GOAL OF THIS PROGRAM IS THE DEVELOPMENT AND COMMERCIALIZATION OF PROTON ACCELERATORS SUITABLE FOR RADIATION THERAPY OF CANCER IN HOSPITAL OR CLINICAL SETTINGS. FOR THIS PURPOSE THE ACCELERATOR SHOULD HAVE AN ENERGY UP TO 250 MEV, AND MUST BE SIMPLE, RELIABLE, AND INEXPENSIVE COMPARED TO EXISTING ACCELERATORS FOR PHYSICS APPLICATIONS. IN ADDITION, WITH SUFFICIENT INNOVATION, IT COULD ...

THE ROLLER PUMP, USED TO PUMP BLOOD FLOW DURING CARDIOPULMONARY BYPASS AND TO PROVIDE LONG-TERM CIRCULATORY SUPPORT, IS A CONSTANT-BLOOD-FLOW DEVICE. IT MAINTAINS CONSTANT FLOW INDEPENTLY OF THE CLINICALLY EXPECTED CHANGES IN INLET PRESSURES. A DECREASE IN BLOOD SUPPLY TO THE INLET OF THE PUMP WITHOUT A CONCOMITANT DECREASE IN PUMP SPEED CAN CAUSE EXCESSIVE SUCTION LEADING TO AIR EMBOLISM, THROMBO ...

DURING THE PAST 20 YEARS, DIFFERENT BIOLOGICAL ACTIVITIES HAVE BEEN DESCRIBED FOR LYMPHOKINES PRODUCED BY ACTIVATED LEUKOCYTES. INTERLEUKIN-1 (IL-1) IS A FACTOR PRODUCED BY ACTIVATED MONONUCLEAR PHAGOCYTES AND IS ESSENTIAL FOR SUPPORTING BOTH T-CELL AND B-CELL RESPONSES. ACTIVATED T CELLS PRODUCE INTERLEUKIN-2 (IL-2), A FACTOR NECESSARY FOR T-CELL PROLIFERATION. THIS SOLUBLE FACTOR EXERTS ITS BIOL ...

THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTION OF THERAPIES FOR INDIVD- UAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHO- TREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DE-TERMINE METHOTREXATE SENSITIVITY BECAUSE OF REQUIREMENTS FORFOR FEEDER LAYERS AND MEDIUM COMPONENTS THAT CAN RESCUE SEN-SITIVE CELLS. THIS PROPOSA WILL,THEREFORE, EVAL ...

NEWLY AVAILABLE TECHNOLOGY MAKES IT POSSIBLE TO CONSTRUCT VIDEO-BASED DEVICES FOR PREPARING AND PRESENTING VIDEO IMAGES THAT INCORPORATE FUNCTIONS OF MANY DIFFERENT TYPES OFIMAGE PRESENTATION SYSTEMS CURRENTLY IN USE IN LEARNING, BEHAVIOR, AND VISION RESEARCH. THE IMAGE EDITOR WOULD INCLUDE THE CAPACITY TO TAKE SELECTED PORTIONS OF VIDEO IMAGES AND REARRANGE THEM AS DESIRED TO CREATE A STIMULUS IM ...

TO FURTHER BIOMEDICAL AND CLINICAL RESEARCH INTO THE AGING PROCESS, A VIDEO-RECORDING SYSTEM PERMITTING THE GENERATION OF A VIDEO DATA LIBRARY OF FALL EVENTS IS NEEDED. THIS PROPOSAL DELINEATES THE FUNCTIONAL REQUIREMENTS OF A VIDEO-RECORDING SYSTEM THAT WOULD AUTOMATICALLY RECORD FALL EVENTS. ITS UNIQUE FEATURES WILL INCLUDE THE ABILITY TO RECORD THE ENTIRE EVENT, INCLUDING THE CIRCUMSTANCES AND ...

HISTAMINE IS AN IMPORTANT BIOCHEMICAL MEDIATOR THAT CAUSES ALLERGIC SYMPTOMS. IGE MOLECULES HAVE A HIGH AFFINITY FOR RECEPTORS ON BASOPHILS. THE PRESENCE OF SPECIFIC ALLERGENS WILL BRIDGE IGE BOUND ON BASOPHIL AND INITIATE A CHAIN OF EVENTS LEADING TO HISTAMINE RELEASE. QUANTIFYING BASOPHIL-HISTAMINE RELEASE ESSENTIALLY MEASURES THE CELL-BOUND, ALLERGEN-SPECIFIC IGE AND WILL ALLOW EVALUATION OF A ...

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