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Project Summary Original Fast-Track Project SummaryCurrent bone grafting techniques for functional rehabilitation with dental implants have limitations – high-cost, difficulties with fixation and stabilization, insufficient bone regeneration, high morbidity using autogenous block grafts and prolonged healing of up to 9 months. Existing synthetic bone fillers cannot match defect shape and volume, ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project results from the ability to design a reusable nanofiltration membrane platform for wastewater treatment. Energy-efficient and effective wastewater treatment for water purification and reuse remains a tremendous challenge because safe and reliable approaches are often capital and energy intensive. The ...

SUMMARY ABSTRACT African Americans are disproportionately affected by chronic and end stage kidney diseasewhileof patients on dialysis are African Americanonlyof the U Spopulation is African AmericanOne factor contributing to this disparity is the high incidence of autoimmune diseaseespecially systemic lupus erythematosusSLEpresent in the African American populationLupus nephritis is a common comp ...

The current inability to effectively deliver corrective doses of lysosomal enzymes to key cells involved in cardiovascular and cerebrovascular disease remains a significant hurdle for rare lysosomal disordersLSDsuch as Fabry disease and other diseases with significant cardiovascular pathologiesBioStrategies LC is developing the plant lectin RTB as a carrier capable of expanding enzyme delivery toh ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop a swarm 3D printing and assembly (SPA) platform via the cooperation of multiple 3D printers and assembly robots. The SPA platform provides a new approach for faster and affordable large-size printing with multiple materials. It addresses several major barriers (e.g., limited prin ...

For NASA#39;s space missions, water must be carried from Earth or generated by fuel cells, for the use of oxygen generation, drinking, food reconstitution, oral hygiene, and hygienic uses (showers, handwashing, and urine flushing). The high launch costs of fresh water to space and environmental health of crewmembers are the two major factors for water reclamation and reuse. Urine is expected to co ...

NASA has demonstrated a resolve to land instruments on the corrosive, high-pressure (~100 bar), high-temperature (470deg;C) surface of Venus. NASA Glenn Research Centerrsquo;s JFET-R technology is the only one that has shown 1000rsquo;s of hours operation under Venus surface conditions. The limitation of this process is that the current integrated circuit die and feature sizes make it impractical ...

Geothermal resources have the potential to provide a significant, carbon-free baseload power for the US. Accessing geothermal resources requires drilling operations that must operate at high temperature and are, by nature, high cost; drilling can account for up to 50% of the cost of the development for a geothermal project. When last studied, experts concluded that as much as 200,000 exojoules of ...

NASA has invested significant time and money in developing high-temperature technologies for Venus surface exploration. Due to the harsh environment outside an insulated lander body (~462deg;C, 92 bar pressure, CO2 atmosphere), conventional, high-TRL components and materials will not survive, even for a short duration mission lasting only a few hours.To meet this need, Ozark IC has worked with NAS ...

A critical problem inherent in the available commercial-off-the-shelf (COTS) QSFP+, and related transceiver (TRX) modules, E/O connectors and interfaces, is that none are designed and manufactured per relevant military standards; and therefore, all will suffer routine and frequent failures in environments that induce high vibration, radiation and/or broad thermal operating conditions. These failur ...