Award Data

pathogens in marine aquaculture waters. Phase II research will look to improve sample concentration, cell lysis, and DNA purification techniques that were developed in Phase I. More specifically, optimization of the prototype lysis/elution fluid will be further developed for cell lysis using BSL-1 organisms, Vibrio harveyi, a surrogate for pathogenic Vibrio ssp. Techniques will be developed to ove ...

With the advent of precision agriculture the way we farm is changing. Technologies exist to addprecision to all aspects of the farm; however these practices all require information that is notreadily available to the small farm. Current field mapping technology has a financial and timecommitment that puts it out of reach of small farms. The aim of the proposed research is to enableprecision agricu ...

This Small Business Innovation Research Phase II project will develop a commercially-viable device that uses micro-scale acoustic streaming (low frequency sound energy) to deliver mixing to the interior of three-dimensional (3D) scaffolds used for stem cell cultivation applications. The enabling advantage of low frequency sound energy is the ability to generate micro-scale mixing in and around sca ...

Project SummaryThere are currently no approved vaccines for most emerging biological pathogens (Ebola, Chikungunya, MERS CoV, SARS, Zika), opportunistic infections (S. aureus, Candidiasis, adenovirus) or potential bioterrorism agents (Y. pestis, B. Pseudomallei, F. tularensis, Bunyaviridae, Flaviviridae), and therapeutic interventions such as antibiotics and antivirals are only effective for a sel ...

Project Summary Acquired epilepsy results from acute brain injury, such as traumatic brain injury (TBI). Acquired epilepsy is a major public health issue with inadequate treatment and diagnostic options. There are no biomarkers that assist in the prediction or diagnosis of acquired epilepsy. Project isoPTE will use two animal models of epilepsy to determine whether plasma microRNA (miRNA) biomarke ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to reduce the cost and increase the quality and throughput of mass spectrometry research through the development of advanced analytical software. Biomedical, biotech, agricultural, and chemical companies spend an estimated $15B per year on mass spectrometry because of the commercial value ...

Satellites provide valuable data for cloud, precipitation, and radiative transfer research.nbsp; Supporting in-situ atmospheric measurements of cloud properties are essential.nbsp; While research aircraft carry the best in-situ instruments, the aircraft and instruments are too expensive to provide sufficient coverage.nbsp; Anasphere is developing a suite of low-cost, balloon-borne instruments that ...

! Project Summary The objective of this SBIR Phase II project is to optimize and validate a prototype assay for ligand bias to be used in screening drugs that target seven transmembrane G- protein coupled receptors (GPCRs). The assay is based on genetically-encoded fluorescent biosensors that report signaling with a change in fluorescence intensity. Aim 1 of this project involves engineering and t ...

This SBIR Phase II effort will advance a new ARCSTONE instrument for calibrating lunar reflectance from TRL 2 to TRL 4. The new instrument, conceived in the Phase I effort, will be much smaller than first-generation units and fit within a 6U satellite payload with substantial margin. This system will utilize a single focal plane array and span the spectral range of 350-2,300 nm. Optical modeling i ...

PROJECT SUMMARY The objective of our program is to develop a safe and effective nonopioid analgesic for the treatment of neuropathic pain, such as pain associated with chemotherapy-induced peripheral neuropathy, that targets an isoform of the voltage-gated sodium ion channel, NaV1.7. Voltage-gated sodium channels are involved in the transmission of nociceptive signals from their site of origin in ...