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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. An ODNP Probe to Study Hydration Dynamics in Membrane Protein

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 400

    DESCRIPTION provided by applicant The proposed research focuses on the development of a cost effect turn key probe for liquid state Overhauser Dynamic Nuclear Polarization ODNP spectroscopy to study the site specific translational dynamics of water molecules located at the interface of bio macromolecules such as membrane proteins It will allow researchers to readily perform ODNP experiments ...

    SBIR Phase I 2015 Department of Health and Human Services
  2. TDP-43 aggregation inhibitors for the treatment of ALS

    SBC: Aquinnah Pharmaceuticals Inc.            Topic: 105

    DESCRIPTION provided by applicant There is currently no therapy for Amyotrophic Lateral Sclerosis ALS which is a universally fatal neurodegenerative disease that afflicts over out of every individuals Protein aggregation has been implicated as a primary driving force in ALS and multiple other neurodegenerative illnesses TDP is the principle component of the protein aggregates i ...

    SBIR Phase I 2015 Department of Health and Human Services
  3. Development of a low-cost, portable autorefractor for the measuring of refractive errors in low-resource settings

    SBC: PlenOptika, Inc.            Topic: NEI

    DESCRIPTION provided by applicant andquot Development of a low cost extended range autorefractorandquot This project proposal seeks to develop technologies that will lower the cost of and increase the accessibility of refractive eye care especially in low resoure settings We propose to advance our previously developed low cost handheld device capable of automati ...

    SBIR Phase I 2015 Department of Health and Human Services
  4. Whole Eye Biometry System

    SBC: Physical Sciences Inc.            Topic: N

    DESCRIPTION provided by applicant Physical Sciences Inc PSI proposes to demonstrate a new dual conjugate dual band approach to whole eye optical biometry We will adapt a high speed SDOCT based scanning imaging system design recently developed for corneal scleral topography for application to the whole eye That system was based upon an ellipsoidal optical scanning imaging design that pro ...

    SBIR Phase II 2015 Department of Health and Human Services
  5. A novel pre-defined CDR library for selection of affinity reagents

    SBC: AXIOMX INC            Topic: 300

    DESCRIPTION provided by applicant The most commonly used method for generating antibodies is through immunization of animals However this method is generally low throughput expensive time consuming and the antibodies generated are not always renewable Recombinant antibodies rAb like single chain variable fragments scFv have many attractive attributes compared to polyclonal antisera ...

    SBIR Phase II 2015 Department of Health and Human Services
  6. ASTROCYTE ACTIVATION BY SMALL MOLECULE P2Y1 AGONISTS FOR TREATMENT OF TBI

    SBC: ASTROCYTE PHARMACEUTICALS INC.            Topic: 105

    DESCRIPTION provided by applicant Traumatic brain injuries TBI are an area of significant unmet need with no approved therapeutics and a national burden of $ billion annually Astrocyte Pharmaceuticals is developing a small molecule pharmaceutical agent that would be administered by intravenous injection by emergency responders or a medical professional within hours of injury to limit n ...

    STTR Phase I 2015 Department of Health and Human Services
  7. Immune modulation of radiation therapy with Flt3 ligand

    SBC: AVANT IMMUNOTHERAPEUTICS, INC.            Topic: 102

    DESCRIPTION provided by applicant This proposal is a unique collaboration between a small but full capability biotechnology company and an academic institution specialized in radiation therapy Stereotactic radiosurgery SRS is being frequently used to control macroscopic tumor in patients with limited metastates The success of SRS in controlling macroscopic disease has generated enthusi ...

    SBIR Phase II 2015 Department of Health and Human Services
  8. Subvocal Speech for Augmentative and Alternative Communication

    SBC: ALTEC Inc            Topic: NIDCD

    DESCRIPTION provided by applicant This Phase II SBIR is prompted by the need for more effective Augmentative and Alternative Communication AAC devices for persons unable to communicate through vocalization The project follows our preliminary work which convincingly demonstrated that surface electromyographic sEMG signals recorded from speech articulation muscles can provide a new and effe ...

    SBIR Phase II 2015 Department of Health and Human Services
  9. Self-Directed Online Training Intervention for Chinese Dementia Caregivers

    SBC: Environment And Health Group, Inc.            Topic: NIA

    DESCRIPTION provided by applicant The objective of this Phase II application is to develop an online self directed learning SDL intervention program that seeks to improve caregiving and self care skills among ethnic Chinese dementia caregivers The benefits of such a product may include improved psychological health in caregivers and a reduction in behavioral disturbances among elderly care r ...

    SBIR Phase II 2015 Department of Health and Human Services
  10. Development of cGMP Manufacturing Process for CBD

    SBC: APHIOS CORPORATION            Topic: NIDA

    DESCRIPTION provided by applicant Medical marijuana is now approved in states and the District of Columbia for several medical conditions such as cachexia cancer chronic pain epilepsy and other disorders characterized by seizures glaucoma HIV AIDS Multiple Sclerosis muscle spasticity and nausea Progress has been made on several fronts on the use of cannabinoids for medical use such ...

    SBIR Phase II 2015 Department of Health and Human Services

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