Award Data

DESCRIPTION provided by applicant Identification of Biomarkers of Cardiotoxicity using Metabolomics of Human Pluripotent Stem Cell Derived Cardiomyocytes Project Summary Abstract Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of FDA approved drugs from the market The purpose of this proposal is to improve public health as well a ...

DESCRIPTION provided by applicant We propose to demonstrate the strength of combining our engineered tissue based drug screening approach and a systematically organized mixture based chemical library This approach could become an ultimate tool to develop treatments for complex diseases such as cardiac fibrosis without known drug targets initially Heart failure is the most common cause of ho ...

DESCRIPTION provided by applicant Significance Accurate targeting guidance and monitoring of interventional therapy in the brain are critical for maximizing their effectiveness and safety during and following neurosurgical procedures Magnetic resonance imaging MRI is a critical tool for planning and guiding neurosurgical procedures In most cases the MRI is obtained during a pre operative ...

DESCRIPTION provided by applicant This Phase II project is motivated by current issues associated with screening for retinopathy of prematurity ROP ROP is the leading cause of blindness in infants In recent years the number of infants at risk for ROP has been increasing In the United States the rate of prematurity has risen from of all births in to in for a total of ov ...

DESCRIPTION provided by applicant The long term objective of this project is to engineer test validate and commercialize the i RxCamandquot a low priced portable and easy to use retinal camera Because of our Phase I technical accomplishments and demonstrated effectiveness we can achieve the overarching goal of this Phase II final verification and validation of the low priced non mydr ...

DESCRIPTION provided by applicant The human transcriptome is significantly more complex than its cognate genome due to the hundreds of thousands of possible isoforms allele specific expression issues variable RNA editing changes and differential expression patterns spanning cell types developmental stages and physiological stresses Next generation sequencing NGS platforms are fundame ...

DESCRIPTION provided by applicant The goal of iFIT Prosthetics LLC r and its founder was to create and commercialize a modular immediate fit fully adjustable transtibial prosthesis system suitable for mass production using high strength polymer materials that are injection molded at a fraction of the cost of conventionally made prostheses This goal was achieved and now the aims of this P ...

DESCRIPTION provided by applicant A post antibiotic era of multiple drug resistance has begun to threaten the health and well being of mankind A crucial limitation in economically converting untapped natural product potential to final scalable production is the lack of next generation tools to effectively access the full medicinal impact of natural environments This project utilizes innovativ ...

Summary abstract The proteins encoded by the human genome may participate in as many as pairwise protein interactions and nearly every major process in a cell is carried out by assemblies of or more interlocking protein molecules Bruce Alberts Cell However there are no commercially available expression systems for regulated expression of multi subunit protein complexes The ...

DESCRIPTION Infections are a leading cause of mortality in adult and pediatric ICUs Earlier diagnosis and treatment of infection could significantly reduce patient morbidity and mortality Unfortunately current methods of detection cannot routinely detect infection early in the disease course Isomark has developed a breath based early detection technology biomarkers and instruments for detect ...