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DESCRIPTION provided by applicant Intracerebral hemorrhage ICH is a major public health problem with highest mortality rate of all stroke subtypes and long term disability Since there are no available FDA approved therapies for ICH it is of enormous importance to establish effective treatment for this medical condition Following ICH the deposited blood is damaging initially via compression ...

DESCRIPTION provided by applicant Influenza viruses constantly undergo antigenic changes which pose great challenges for development of vaccines against influenza epidemics as well as pandemics There are at least known subtypes of influenza A viruses which fall into two broad phylogenetic groups Current trivalent inactivated vaccines TIV H H and B for seasonal influenza are not suit ...

DESCRIPTION provided by applicant The Specific Aim of this proposal is to test the feasibility of developing utilizing and evaluating a web based diabetes self management support DSMS training program that is culturally tailored for the African American community Effective self management is the key to improving diabetes outcomes avoiding complications and reducing costs Ongoing mainte ...

DESCRIPTION provided by applicant Sickle cell disease SCD is the most common hemoglobinopathy associated with significant life long morbidity and premature mortality Over children are born with SCD in sub Saharan Africa annually more than of them die in early childhood Most of these deaths could be prevented through simple and inexpensive prophylaxis if SCD was diagnosed soon ...

DESCRIPTION provided by applicant Ovarian cancer is the fifth most leading cause of cancer related deaths in women in the US It has been observed that the cancer relapses within relatively short periods of time even after the surgery and chemotherapy Therefore immunotherapeutic strategies may serve as an alternative to control the recurrence or progression of ovarian cancer Oral vaccines ar ...

DESCRIPTION provided by applicant This SBIR Phase I project will develop a novel mobile framework to measure left ventricular ejection fraction as a marker for systolic dysfunction using automated non invasive analysis of cardiac signals Heart disease is the leading cause of death for men and women accounting for more than one third of all U S deaths In total costs associated w ...

Increasing the autonomy of unmanned vehicles potentially reduces operator workload and cognitive load. Realizing the promise of autonomy however, is difficult when deploying in environments with mobility and visibility challenges, enemy threats, risks of endangering civilians, and limited communication. Achieving full autonomy in the face of these challenges is both a hard technical problem and do ...

DESCRIPTION provided by applicant In the U S there are more than hospitalizations annually related to burn injury with more than of these admissions to the U S burn centers resulting in more than $ billion in healthcare costs Burn wounds may become infected through patient self infection from their own normal flora or by nosocomial infection between healthcare provider or fa ...

DESCRIPTION provided by applicant VisionQuest Biomedical and its collaborators have assembled a team of inter disciplinary scientists with considerable experience in automated retinal image analysis clinical ophthalmology with specialized research in malarial retinopathy MR and cerebral malaria diagnosis CM This team will develop and test an automated MR screening software system integra ...

DESCRIPTION provided by applicant Tuberculosis TB is a chronic infectious disease that infects approximately one third of the worldandapos s population Eighty five percent of the estimated million new cases of TB in occurred in resource limited countries located in Asia and Africa In there were million deaths from TB among HIV negative patients and additional TB d ...