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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. iKITT Innovative Keratitis Identity Type Test

    SBC: LYNNTECH INC.            Topic: Y

    PROJECT SUMMARY Ulcerative keratitis caused by infectious microbes (bacteria, fungi, amoebae and viruses) or due to eye trauma or chemical exposure is a medical problem of significant concern. Annually, keratitis accounts for 930,000 Doctor’s office and outpatient clinic and 58,000 emergency department visits, resulting in $175 million in direct healthcare expenditures and consumption of over 25 ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Novel inhibitor of PDE4 for the treatment of opioid use disorder

    SBC: FANNIN PARTNERS LLC            Topic: NIDA

    Project Summary Currently, opioid-use disorders are mitigated by replacing illicit opioids with prescription opioids, like methadone and buprenorphine. While this may work for some patients, few patients successfully reach opioid-abstinence. Thus, new agents targeting opioid-use disorders via non- opioid approaches are overdue. One-way opioids induce such tolerance and dependence is through a seco ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Low Burden Wearable Sensor System for Diagnosing Obstructive Sleep Apnea in Older Adults

    SBC: Sibel Inc.            Topic: NHLBI

    1 PROJECT SUMMARY: andgt;50% of adults aged 65+ have a high risk of obstructive sleep2 apnea (OSA), a condition that increases the risk of stroke, heart attack, and death. The3 prevalence of OSA is at least twice as high in older adults compared to younger age4 groups. Despite this increased risk and prevalence, only 8% of older adults at high risk5 of OSA receive evaluation by either in-laborator ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Developing Versatile and Facile Chemical Synthesis Methodologies for Preparation of 18F-Tracers for PET Imaging

    SBC: TheraCea Pharma LC            Topic: NIBIB

    Project Summary/Abstract Positron emission tomography (PET) is an exquisitely sensitive and quantitative imaging modality with numerous applications in oncology, neuroimaging, infection/inflammation, and cardiology. PET has great potential for hybrid imaging techniques in which nuclear medicine can be combined with anatomic imaging techniques such as magnetic resonance imaging (MRI). Such approach ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Acoustoelectric Echocardiography for Improving Prognosis and Guiding Treatment Decisions for Advanced Arrhythmias

    SBC: ElectroSonix LC            Topic: NHLBI

    ABSTRACT Atrial Fibrillation (AF) is characterized by a disorganized activation of the atrium leading to impaired cardiac function and more serious complications like embolic stroke, worsening heart failure, and increased mortality. AE affects 9% of the U.S. population (2% younger than 65) and contributes to 750,000 hospitalizations and 130,000 deaths per year. There is a clear unmet clinical need ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a robotic ankle assist device to improve mobility in individuals with movement disorders.

    SBC: BIOMOTUM, INC.            Topic: NICHD

    PROJECT SUMMARY/ABSTRACT A child’s ability to engage in physical activity is essential to their health, independence, and general well-being. Many of the 500k children in the United States with cerebral palsy (CP), the most common cause of pediatric physical disability, have difficulty walking and participating in physical activity. This reduced physical activity in CP is a primary contributor t ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Development of Novel Herbal Therapy for Prevention of Irinotecan-induced Severe Delayed Onset Diarrhea

    SBC: SANARENTERO LLC            Topic: NCCIH

    PROJECT SUMMARY / ABSTRACT Cancer is the second leading cause of death in the United States. According to American Cancer Society statistics, about 1.76 million new patients are expected to be diagnosed with cancer and about 600,000 people are expected to die due to cancer in the United States in 2019. Approximately 6-10% of the total cancer patients are diagnosed with stage IV/metastatic cancer, ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Cryopreserved preparations of male and female brain cells to study gender-related issues

    SBC: SPOT CELLS LLC            Topic: 999

    PROJECT SUMMARY Cryopreserved brain cells can be stored in liquid nitrogen indefinitely and revived when needed to conduct research related to human health. To prevent or reduce the ice-induced cell damage caused by freezing, the media used for cryopreservation are supplemented with cryoprotectants. Dimethyl sulfoxide (DMSO) is a cryoprotectant that easily penetrates biological membranes and outpe ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. ApoE isoform-specific glycosylation as diagnostic and prognostic biomarker of Alzheimer's disease

    SBC: ISOFORMIX INC.            Topic: NIA

    PROJECT SUMMARY Brain amyloid-β levels and amyloid plaque loads in Alzheimerandapos;s disease (AD) have been shown to be apolipoprotein E (apoE)-isoform dependent (E4andgt;E3andgt;E2), but the exact mechanisms by which the isoforms (especially E4) differentially contribute to AD pathogenesis are not completely understood. Very little is known about the role of glycosylation of apoE in AD. Current ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Novel wear resistant coatings with gradient interfaces for long lasting hip prostheses

    SBC: DURAHIP, LLC            Topic: NIAMS

    PROJECT SUMMARY The broader impact of this Small Business Innovation Research Phase I project is to improve the clinical success and longevity of orthopedic prostheses for younger and active Americans to get relief from debilitating pain and to improve the quality of their life. The long-term survival of total hip replacements (THR) in young, active patients with higher demands remains a challenge ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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