Award Data

This Fast-Track application proposes to adapt to Chinese a previously developed self-administered, multimedia version of the Addiction Severity Index (ASI), called the ASI-MV. The ASl is the most widely used measure of addiction severity. It is now mandated in some governmental jurisdictions and is rapidly becoming a standard assessment for chemical dependency. This project will extend the ASI-MV ...

DESCRIPTION (provided by applicant): Based on recent progress in sequencing the human genome, a new goal has emerged: to express and analyze the human proteome. The development of proteome arrays will accelerate progress in several key areas of biology and medicine including mapping cellular pathways, discovering new drug targets and identifying disease related biomarkers. However, the production ...

DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) has become an important tool in the fight against cancer. PET is now being used in diverse studies ranging from basic research in animal models of cancer in the mouse, through to diagnosis and staging of cancer patients in the clinic. It is clear that PET technology is playing a prominent and an increasingly visible role in mo ...

DESCRIPTION (provided by applicant): Nuclear medicine techniques (such as SPECT) have the potential to become powerful new tool in imaging biological processes in small laboratory animals. With the ever increasing number of human disease models, particularly in the smaller animals such as mice and rats [Bernstein, Doetschman, Hanahan], the potential of high resolution nuclear medicine technology t ...

N/A

THE OBJECTIVE OF THIS PROGRAM IS TO DEVELOP A LOW-COST, FIBEROPTICALLY COUPLED RAMAN SPECTROMETER FOR BIOLOGICAL, BIOCHEMICAL, BIOPHYSICAL, AND CLINICAL APPLICATIONS. RAMAN SPECTROSCOPY PROVIDES MOLECULAR FINGERPRINTING CAPABILITIES AS DOES INFRARED SPECTROSCOPY, BUT UNLIKE INFRARED, RAMAN ISAPPLICABLE TO AQUEOUS ENVIRONMENTS. THE PROPOSED INSTRUMENTWILL PROVIDE THE SCIENTIFIC COMMUNITY WITH A FLE ...

DESCRIPTION (provided by applicant): This is a proposal to test the feasibility of a "Smart Telescope" for use to improve the ability of visually impaired persons in tasks such as travel, navigation and social interactions. Advances in low-power high-speed portable computers combined with novel computer vision algorithms enable us to build an affordable, portable, and cosmetically acceptable digit ...

DESCRIPTION (provided by applicant): Measurement of transdermal alcohol is potentially a very unobtrusive, inexpensive and accurate way of continuously studying the alcohol consumption behavior of subjects in research and field settings as well as for monitoring special populations. Several innovative technological advances in ectrochemical sensing, materials science and engineering are proposed ...

DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop a hand-held device with a plug-and-play nanosensor platform based on biomolecule-gated nanowire field effect transistor (FET) sensors. The principle of the nanowire FED sensor has been demonstrated by Prof. Charlies Lieber's group at Harvard University. The technology requires no label and combines the specificit ...

The objective of this proposal is to develop and validate synthetic calibration standards for clinical immunohistochemical (IHC) assays. IHC assays are the standard of care in cancer diagnosis and surgical pathology, but they suffer from a serious problem with inherent variability. Accuracy in testing is hampered by the lack of standardized test materials, which prevents the establishment of unifo ...