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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Clinical Trial Enrichment Tool Based on Subgroups Defined by Machine Learning Predictive Models

    SBC: ORIGENT DATA SCIENCES, INC.            Topic: 102

    ABSTRACT Neurodegenerative disordersincluding amyotrophic lateral sclerosisALSFriedreichandapos s ataxiaFAmultiple sclerosisMSDuchenne muscular dystrophyDMDAlzheimer s diseaseADParkinson s diseasePDand Huntington s diseaseHDare characterized by heterogeneous disease progressionEfforts to identify responder subgroups may uncover subgroups that are more homogeneous in disease related features than t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A cloud-based WGS platform for establishing phylogeny within epidemic outbreaks at hospitals

    SBC: ICBiome            Topic: NIAID

    Outbreaks have become a significant public threat in hospitalsimpacting both patient lives and creating a financial burdenWith the increasing rise in antibiotic resistancenew interventions are urgently needed to contain ongoing outbreaksRecent studies have confirmed that whole genome sequencingWGSis able to identity unique mutations within each outbreak strainwhich can then be utilized to establis ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. ACTIVE CONTOURS FOR APPLICATIONS IN IMAGING CYTOMETRY

    SBC: Perceptive Sciences            Topic: N/A

    N/A

    SBIR Phase I 1997 Department of Health and Human Services
  4. ADENOSINE ANTAGONIST FOR CARDIOPULMONARY RESUSCITATION

    SBC: Discovery Therapeutics, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  5. A DNA nanotechnology vaccine platform for delivery and translation of HIV-1 1086C gp160 Env LNP

    SBC: PARABON NANOLABS, INC.            Topic: NIAID

    PROJECT SUMMARY ABSTRACT The human immune response to HIVis complex with the virus demonstrating remarkable evasion mechanismsSignificant progress has recently been made in HIV vaccine development based on early stage clinical trials and subsequent investigations into the nature of protective immunitySeveral promising messenger RNAmRNAbased HIV vaccines that target the HIV envelope proteinEnvhave ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Advance Directives for Elderly Community Residing Adults

    SBC: HEALTH AND EDUCATION            Topic: N/A

    With the combined effects of a rapidly growing elderly population and advances in medicaltechnology, the need for decision making about appropriate medical treatments for elderly individualshas increased. Education about advance directives, legal documents which identify patients' decisionsregarding medical treatments, has not been systematically directed toward elderly adults residing in thecommu ...

    SBIR Phase I 1994 Department of Health and Human Services
  7. A gel patch for replacing surgical eardrum repair with an office-based procedure

    SBC: TYMPANOGEN, INC.            Topic: NIDCD

    ABSTRACT Chronic perforations of the tympanic membraneTMaffect overpatients in the United States annuallyoften stemming from ventilation tubes inserted in the TM to drain fluid from middle ear infectionsLeft untreatedthese TM perforations can lead to significant morbidities that include recurrent ear infectionconductive and sensorineural hearing lossmastoid bone infectionand cholesteatoma developm ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A Large-Scale Microfluidics Imaging Platform for High-Throughput Toxicity Testing using Canine Intestinal Organoids

    SBC: VIVOVERSE, LLC            Topic: NIEHS

    Project SummaryCurrentlytoxicology studies require a large number of animal testing to identify better and safer drug candidatesIn an attempt to reduce the use of large animals in pharmaceutical industrythere is a need to bridge the gap between the conventional in vitro cell based assay and the non human animal studiesRecentlythreedimensional models are gaining momentum and replacing conventionalD ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Alcohol-Related Categorical Variables

    SBC: MARTINGALE RESEARCH CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1994 Department of Health and Human Services
  10. Alpha/Beta L-Nucleosides--Synthesis & Biological Action

    SBC: LIPITEK INTERNATIONAL, INC.            Topic: N/A

    This grant will study the feasibility of developing convenient, cost-effective methods of synthesisfor L-sugar nucleoside and nucleotide analogue chemotherapeutic agents and to investigate theirphosphorylation and uptake by malignant cells in tissue culture. L-sugar-based therapeutic agents havepotential as anticancer, antiviral, and antiparasitic drugs. During Phase I, we will (a) develop pilot s ...

    SBIR Phase I 1994 Department of Health and Human Services
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