Award Data

New methodologies are being developed for interrupting the Lyme Disease transmission cycle, includiacaricides in reducing an infected tick population, control of Peromyscus spp. by environmental manirodenticidal treatment, and deer population management. A systemic, orally administered acaricide ef(particularly immature statges of Ixodes dammini), feeding on treated animals could break the tick lo ...

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The use of monoclonal antibodies (MABs) in diagnostic and therapeutics applications is on the rise; yet there are limitations to the current hybridoma technology. There is a need to develop less expensive, novel and improved technologies for MAb production. The application of recombinant technology has made it possible to generate single chain, chimeric and humanized MAbs with desired specificity. ...

In the last several years there has been an explosion of information regarding the nature of peptide antigens expressed on human tumors together with class I molecules encoded in the Major Histocompatibility Complex (MHC) and recognized by cytotoxic T lymphocytes (CTL). One very successful approach aimed at the identification of these antigens, termed Direct Identification of Relevant Epitopes for ...

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Adenosine produces coronary vasodilation through activation of A-2a adenosine receptors. However adalso acts at A1 adenosine receptors to slow atrioventricular conduction and when injected into man ican be blocked with A1 receptor antagonists. DTI has synthesized a number of adenosine analogs that2a subtype of adenosine receptor and have identified WRC-0470 as a potent selective short acting corou ...

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Catheters are one of the most commonly used biomaterial implants, (200 million annually in the U.S.). In long term use as for vascular central lines, the urinary tract and peritoneal dialysis, catheters are particularly susceptible to infection. These infections are resistant to antibiotic treatment and persist until removal of the device. Utilizing the concept of Passive Local Immunotherapy, (PL ...

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The objective of Phase I is to develop simple, sensitive and unambiguous chemiluminescent detection of juxtaposed genes in chromosomal translocations associated with many cancers. We propose chemiluminescent assay formats based on simultaneous probing and detection of both genes of a translocation in a single Southern blot. Phase I will prove the feasibility by developing a Southern hybridizatio ...