Award Data

Since the mid-1970's, information on current and emerging drug abuse patterns and trends have beenepidemiologic data derived primarily from national probability samples and population-based surveys.however, there has been increasing interest in use of data generated through ethnographic methods toof drug abusing behavior. While surveys typically answer questions about the nature and extent of dto ...

DESCRIPTION: Cancer treatment by gene therapy, in which an exogenous gene is introduced into tumor cells, is receiving increasing attention. Metabolism of a specific substrate by the enzyme encoded by the transduced gene produces a substance toxic to the tumor. In the most common approach, the gene for the Herpes Virus Thymidine Kinase has been introduced by retroviral transduction. Although p ...

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This research will develop a novel, high throughput method for screening and recovering microorganiproducing antibiotics of interest. The combination of One Cell Systems' gel microdrop encapsulationfluorescence activated cell sorting (FACS), forms the basis for an automated, low unit cost screeninapplicability to the pharmaceutical and chemical industries. By embedding microorganisms of interestmi ...

The limited availability of donor hearts for people with end stage heart failure has driven the condevelopment of mechanical circulatory support systems (MCSSs). MCSSs can be broadly classified intocontinuous flow systems. Pulsatile systems drive blood indirectly through blood pumps, resulting inThis disadvantage of these systems, however, is their relatively large size. Continuous flow systemssim ...

We will develop a computer-assisted system to improve the ability of breast sonography to distinguifrom benign lesions. These are lesions originally detected by mammography and sent to ultrasound forThe lesions are biopsied when they are classified by ultrasound as solid or indeterminate, even thoubenign at biopsy. Because of the large numbers of breast biopsies being performed, even a small impro ...

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Radioactive labeling of proteins using tritium is a very important technique used in neurological ridentify, isolate, and investigate the expression of proteins in biological systems. It is often necradiolabel for this work because 3H in vivo labeled proteins retain their conformal structure and arassays. Currently, many 3H-labeled binding assays are done using inconvenient, time consuming, and et ...