Award Data

PROJECT SUMMARY/ABSTRACTOne in three Latinx report having extreme levels of stress and are more likely to say their stress has increased in the past year. Stress in Hispanics has been linked to high rates of depression, higher cardiovascular disease, and increased diabetes risk. High rates of stress and negative health outcomes among Latinx may be the result of the unique stressors (i.e., accultur ...

PROJECT SUMMARY/ABSTRACTAfrican American men have the highest rate of hypertension (HTN) in the United States. Once diagnosed, they are also less likely than other groups to achieve blood pressure (BP) control. This health disparity is critical, as elevated BP is the primary modifiable risk factor for cardiovascular disease.One reason for this HTN disparity: stress. African Americans experience mo ...

PROJECT SUMMARY/ABSTRACT The 2017 Centers for Disease Control and Prevention’s (CDC) Breastfeeding Report Card reported that despite a high breastfeeding (BF) initiation of approximately 80% among the Hispanic population in the United States (US), less than 25% of infants were exclusively breastfed (EBF) through 6 months, further perpetuating ethnic disparities in chronic diseases such as diabet ...

PROJECT SUMMARY / ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the spinal cord and brain. ALS causes muscle weakness and paralysis and eventually death. According to the ALS Association, every 90 minutes there is a new diagnosis of ALS, as well as an associated death. Nearly 5,000 people are diagnosed with ALS each year and a ...

Administrative Supplement Application PA-20-272 Xenon gas treatment to modulate microglia in neurodegenerative diseases (R41AG073059) ABSTRACT ABSTRACT FROM ORIGINAL APPLICATION Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder. Emerging evidence shows that homeostatic dysregulation of the brain immune system, especially that orchestrated by microglia, plays a significant ...

PROJECT SUMMARY With the rise of artificial intelligence (AI) algorithms in medicine, radiologists have new tools at their disposal to quantitatively assess imaging data. However, in order to unlock this potential, data needs to be shared easily and effectively between all parts of the health information technology (IT) system. The goal of this project is to reduce data access barriers by developi ...

Project Summary/Abstract Physical Sciences Inc. (PSI), in collaboration with the Department of Radiology at Brigham and Womenandapos;s Hospital (BWH), proposes to develop an automated Smart Multi-grid-guidance Template (SMT) technology that will enable magnetic resonance imaging (MRI)-guided transperineal focal therapy improvement of prostate cancer (PCa). Focal therapy that targets localized PCa ...

PROJECT SUMMARY The United States is amid an opioid epidemic. The overall annual cost to society is more than $1 trillion. The COVID-19 pandemic appears to have accelerated the problem, with more than 81,000 individuals dying from overdose in the year ending May 2020. Astonishingly, while more than 2 million individuals have opioid use disorder (OUD), fewer than 35% of these adults received treatm ...

ABSTRACT Contingency management, an incentive-based intervention, boasts a massive research base and has been demonstrated efficacy in increasing drug abstinence and medication adherence in people with opioid use disorder. There is a huge gap between the evidence in support of this approach and its dissemination in practice. A digital health program that surmounts most of the barriers to dissemina ...

Life preserver units (LPU) serve to aid Rotary Wing Naval Aircrew in water survival situations. However, current LPU designs require the crewman to be capable and conscious for inflating the device by manual activation or oral inflation. Lack of consciousness or incapacitating injury has unfortunately led to the loss of life. LPU's are worn around the collar of the aircrew and are activated once t ...