Award Data

Project Summary/Abstract Positron emission tomography (PET) is an exquisitely sensitive and quantitative imaging modality with numerous applications in oncology, neuroimaging, infection/inflammation, and cardiology. PET has great potential for hybrid imaging techniques in which nuclear medicine can be combined with anatomic imaging techniques such as magnetic resonance imaging (MRI). Such approach ...

Abstract The overall goal of this proposal is to combine expertise and approaches from biomedical engineering and critical care medicine to design a universal system to acquire, record and transmit physiological signals from bedside monitored patients. Patient monitors generate over a million datapoints of information per hour, however, only a tiny fraction of those data are transmitted or recorde ...

PROJECT SUMMARY ALS is a devastating neurodegenerative disease with two FDA-approved therapies that can prolong a patient’s lifespan by only a few months. Thus, an effective therapeutic to treat ALS is needed. ALS can arise sporadically or through inherited mutations in one or a combination of several genes. The heterogeneity of ALS makes it difficult to create a therapeutic that can effectively ...

Project Summary/AbstractThe idiosyncrasies of the human brain require that individualized mapping of functional regions be performed before surgical interventions for cancer or epilepsy. The success of this mapping procedure has direct effects on surgical outcomes and preserving cognitive and sensory function post-surgery. Current gold standard procedures for pre-surgical mapping are invasive, tim ...

ABSTRACT Rgenta has developed a robust, innovative, target and lead discovery platform that has identified small molecules that can lower the levels of HTT through a novel mechanism-of-action in RNA-targeting. In this Phase I SBIR project, we aim to develop first-in-class drug candidate compounds for HTT lowering as a new therapeutic approach for treating HD. Our Phase I SBIR proposal has three ai ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop safe and affordable COVID-19 vaccination technology, with broader utility in preventing other types of outbreak in the future. This nov

Project Summary/Abstract The abuse of opioids is a serious national crisis that affects public health as well as social and economic welfare. A 2018 report from the Centers for Disease Control and Prevention (CDC) shows that every day, 128 people in the United States die from opioid overdose. Synthetic opioids (e.g. fentanyl) have become the leading cause of drug-related deaths in recent years. Th ...

Project Summary/Abstract Wearable sensor for opioids detection based on electrochemical sensor arrayintegrated with Bluetooth deviceIn this Phase I project, we will develop the prototype of a wearable device, as a forearm bracelet, for rapid, on-site opioid intake monitoring and alerting. We will demonstrate the feasibility of this approach by fabricating an electrochemical sensor array, sweat sti ...

PROJECT SUMMARY/ABSTRACTAfrican American women are almost twice as likely to be diagnosed with cervical cancer (CC) as white women. Their initial clinical picture is also more negative, characterized by more severe dysplastic changes and later-stage disease. Given this, it is not surprising that Black women are also more than twice as likely to die from CC as compared to white women. Even worse, t ...

SBIR Phase I proposal to demonstrate non-contact,non-destructive in-situ torque and fastener preload measurement for threaded fasteners such as nuts, bolts, and screws.  Conventional NAS and SAE fasteners are used to demonstrate torque and preload sensing methods.  Results are compared and validated with conventional torque wrench measurement, ultrasonic bolt elongation measurements, and cross-c ...