Award Data

PROJECT SUMMARY ABSTRACT Breastfeeding has the potential to reduce health disparities associated with infant mortality and morbidity Breastfeeding rates by ethnicity in the United States show a marked disparity in African American AA women as compared to other groups Barriers to breastfeeding are complex with literature citing a lack of knowledge poor family and social support inhibiting soc ...

ABSTRACT Stroke is one of the leading causes of death and disability in the United States and other developed countriesAboutpeople in the United States have a stroke each yearThe incidence of stroke is expected to increasedue to diabetesan aging population and a rise in obesitywhich is a major public health concern and great economic burden to societyEarly identification of people at risk of strok ...

Project Summary The goal of this project is to significantly enhance our understanding and treatment of inadequate balance responses in the elderly and in patients with neurological impairments following external perturbations such as a slip or trip Our laboratory studies have shown that balance responses can be improved with practice in the elderly and in patients with Parkinsonandapos s disease ...

Project SummaryAging increases the risk of GI disorders such as CRCinflammatory bowel diseaseand appendicitisNIH statistic shows that an estimatedtomillion Americans are affected by gastrointestinal diseases annually and nearlyof older adults have one or more age related digestive symptom each yearUnfortunatelythe increasing global geriatric population base is expected to further worsen this situa ...

Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

The work described in this proposal addresses the clinical deficiency of the currently available oral treatments for hypothyroidism Approximately of persons suffering from hypothyroidism report insufficient symptomatic improvement from levothyroxine T Synthroid alone This is thought to be related to a genetic variation in the enzyme that converts T to T the active form of thyroid hor ...

PROJECT SUMMARY We will develop and commercialize to the research community a new class of glycan specific binding reagents that incorporate the recognition function of variable lymphocyte receptors VLRs the antigen receptors of the adaptive immune system of jawless vertebrates lamprey and hagfish Such reagents are essential to detecting localizing quantifying and establishing biological ...

This project will explore the translational potential of a new PET molecular imaging probe Ga PC for detecting very small cancers and distinguishing between localized and metastasized cancers in bone and soft tissue mouse models Ga PC will be evaluated for metastatic prostate PC and pancreatic PaCa cancers Early detection of the most lethal PaCa with andlt survival for y ...

Blood biopsy test for pan cancer mutations with error checking probes Confidential PI Shafer David A PhD PROJECT SUMMARY GeneTAG Technology www genetagtech com has developed a series of molecular diagnostic assays for cancer and infectious diseases based on DNA amplification and proprietary detection methods Our primary system internal DDS iDDS probes comprises two interacting component ...

This proposal aims to develop a polymer hydrogel strategy that can be used to improve the clinical care of patients receiving brachytherapy for gynecological cancers The biocompatible hydrogel will form in situ after being injected into the vaginal space and later removed by instillation of water to soften the hydrogel for easy extraction This Phase I proposal focuses on optimizing the polymer ...