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PROJECT SUMMARYLyme disease is the most commonly reported arthropod borne infection in the US with recent CDC estimates eclipsingnew cases inIn addition to growing in frequencythe infections have a complex and increasingly severe courseBeginning with mild flu like symptoms and frequently a signature bull s eye rasherythema migransLyme disease can progress to severe articularneurological and cardia ...

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ABSTRACT Traumatic brain injuryTBIis an expanding public health epidemic with complex pathophysiology that is difficult to diagnose and thus treatTBI blood testing should provide simplereliablereal timeobjective diagnostic monitoring and outcome prediction across the entire severity spectrumNeurotrauma biomarkers with insight into underlying TBI processes can address these needsAt UCLADrWanner s t ...

Project Summary This project addresses a critical need for early detection of mild cognitive impairment (MCI) and other Alzheimer's-related dementias (ADRD). Advances in smartphone hardware, computer vision, and machine learning have enabled the possibility of producing smartphone-based cognitive testing applications able to collect electronic sensor data and transform it into highly informative ...

Project Summary Breast cancer remains a leading cause of cancer related death among women in the United StatesMammographythe only cost effective method approved for population screening of breast cancerfails to find cancer in many women and causes too many unnecessary call backs on the restFischer Imaging has developed proprietaryslot scanningtechnology that significantly improves contrast and dou ...

Abstract The current status of opiate abuse in the US has been characterized as arapidly evolving publichealth crisisrequiring the need for new treatments to address the problemPersistent relapse toaddictive drug use is a significant challenge to addiction therapyMedications targeting theneurobiology underlying relapse offer additional avenues for treatmentGlutamate signaling iscritically involved ...

Summary Abstract Indirect calorimetry is based on measurement of the exchange of respiratory gasesAll aerobic energy releasing reactions in the body use oxygenoxygen consumptionV Ois proportional to energy expenditureEEResearchgrade indirect calorimetry systems measure V Ocarbon dioxide productionV COand minute ventilationV Ebreath by breath and then average results over multiple breaths to obtain ...

PROJECT SUMMARYThe specific focus of this phase I application is to develop liver tissue targeting histone deacetylase inhibitorsHDACifor targeted hepatocellular carcinomaHCCtherapyHCC accounts for overof all liver cancers and is one of the most common types of malignanciesHCC is associated with a relatively lowyear survival rateand it is the third leading cause of cancer death globallySurgical re ...

Project Summanry Abstract Although abirateroneZytigaand enzalutamideXtandirepresent significant advances in the treatment of metastatic castration resistant prostate cancermCRPCall eventually acquire drug resistance over time and become lethalThereforenew research strategy and intervention are urgently needed to develop effective therapy for CRPCWe have shown that galectinGala beta galactoside bin ...