Award Data

DESCRIPTION (provided by applicant): This project develops A2A adenosine receptor (A2AAR) agonists as adjuncts to antibiotics for the treatment of anthrax septicemia. It responds to the urgent need for better treatment of highly lethal infections by this bioterrorism/biowarfare agent. Phase I has two aims, pharmaceutical development and documentation of efficacy in clinically relevant settings. Th ...

DESCRIPTION (provided by applicant): The central goal of this research is to develop a new drug to prevent spinal cord reperfusion injury secondary to aortic clamping that occurs frequently during thoracic surgery. Irreversible spinal cord injury resulting in paraplegia or paraparesis is the single most devastating complication of surgery on the thoracic and thor ...

DESCRIPTION (provided by applicant): The central goal of this research is to develop a new drug to prevent spinal cord reperfusion injury secondary to aortic clamping that occurs frequently during thoracic surgery. Irreversible spinal cord injury resulting in paraplegia or paraparesis is the single most devastating complication of surgery on the thoracic and thor ...

epsis syndrome is the 11th leading cause of death in the United States ( about 900,000 new cases per year) with a mortality of about 35 percent. The need for adjunctive therapies is urgent. In Phase I of this SBIR award we documented the anti-inflammatory effects of adenosine A2A receptor (A2AAR) agonists on isolated immune cells and have observed ramatically improved survival in mouse models of I ...

epsis syndrome is the 11th leading cause of death in the United States ( about 900,000 new cases per year) with a mortality of about 35 percent. The need for adjunctive therapies is urgent. In Phase I of this SBIR award we documented the anti-inflammatory effects of adenosine A2A receptor (A2AAR) agonists on isolated immune cells and have observed ramatically improved survival in mouse models of I ...

This innovation proposes the use of a thin film stratospheric balloon to lift a launch vehicle with a payload to an altitude above most of the Earth's atmosphere, then ignite the launch vehicle rocket motor. It will have the capability to carry the payload to its final destination, either into Earth orbit or to the mission design goal. This launch system will eliminate the first stage rocket thr ...

ALGORITHMS ARE DERIVED THAT DEFINE THE PATHS OF MAXIMUM COHERENCY FOR A SEISMIC EVENT GENERATED BY FIRING AN ARTILLERY WEAPON FROM AN ARBITRARY LOCATION. SIGNAL EXTRACTION TECHNIQUES ARE DESCRIBED TO EXTRACT THE COHERENT SIGNAL FROM AN EVENT RECORDED ON MULTIPLE RECEIVERS. SIMULATED BATTLEFIELD RECORDINGS ARE GENERATED BY TREATING THE SEISMIC SIGNATURE OF ARTILLERY WEAPONS AS IMPULSE RESPONSES FRO ...

AbTech Corporation proposes to apply its unique Statistical Network ModelingTM technology to develop a non contact prognostic assessment tool that 1) acquires, processes, and analyzes electronic radiated signal data, 2) learns the expected characteristics and patterns of specific radiated signals measured from microelectronic semiconductor devices using AbTech's statistical network modeling techno ...

INNOVATIVE ARTIFICIAL INTELLIGENCE TECHNIQUES HAVE THE POTENTIAL TO SOLVE MANY COMPLEX AIR FORCE PROBLEMS. ADVANCES IN COMPUTING SPEED AND EXISTING SOFTWARE TECHNOLOGY ALONE ARE UNLIKELY TO RESULT IN REAL-TIME AERONAUTICAL SYSTEMS CAPABLE OF MEETING THE COMPLEX REQUIREMENTS OF THE AIR FORCE MISSION. RATHER, AN ALTERNATIVE METHODOLOGY SUCH AS ABDUCTIVE TECHNOLOGY, A NEW TECHNOLOGY PRESENTED IN THIS ...

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