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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 39 results
 
  • Record 1 TO 39

  1. RAPID ASSAY FOR HUMAN A(1)-PROTEINASE INHIBITOR DEFICIENCY

    SBC: Athens Research And Technology            Topic: N/A

    THIS PROPOSAL INVOLVES THE DEVELOPMENT OF A SIMPLE ASSAY FORMEASURING FUNCTIONAL (1)-PROTEINASE INHIBITOR LEVELS IN HUMAN TISSUES. THE PROCEDURE UTILIZES THE FACT THAT INCUBATION OF EXCESS PORCINE PANCREATIC ELASTASE WITH EITHER PLASMA OR SERUM SAMPLES WILL RESULT IN COMPLEX FORMATION WITH FUNCTIONAL (1)-PROTEINASE INHIBITOR IN THESE FLUIDS. RESIDUAL ENZYME ACTIVITY CAN THEN BE CALCULATED AND A DE ...

    SBIR Phase II 1989 Department of Health and Human Services

  2. POLYMERIC MEMBRANE APPLICATIONS TO IMPROVE CELL CULTURE

    SBC: Athens Research And Technology            Topic: N/A

    CAPS OF CELL CULTURE FLASKS USED IN CONJUNCTION WITH BICARBONATE BUFFER SYSTEMS MUST BE LEFT PARTIALLY OPEN TO ALLOW FOR CARBON DIOXIDE EXCHANGE. THE PRESENCE OF AIRBORNECONTAMINANTS OR LEAKAGE OF MEDIA INTO THE THREADS OF THE CAPTHREATENS TO CONTAMINATE THE CULTURE. CONVERSELY, TIGHTENING THE CAP TOO MUCH LEADS TO THE LOSS OF SOME CULTURES BECAUSE OF IMPROPER GAS EXCHANGE. CELLGRO RESEARCH (CGR) ...

    SBIR Phase I 1989 Department of Health and Human Services

  3. PREVENTION OF CALCIFICATION OF CARDIOVASCULAR PROS

    SBC: Biomedical Design Inc.            Topic: N/A

    THE FAILURE OF CARDIOVASCULAR BIOPROSTHESES DUE TO CALCIFICATION IS A MAJOR CLINICAL PROBLEM. THE DERIVATIVE OF A NATURAL COMPOUND HAS BEEN SYNTHESIZED; WHEN IT REACTED WITH GLUTARALDEHYDE-PRESERVED TISSUE, IT PREVENTED CALCIFICATION IN SUBCUTANEOUS BOVINE PERICARDIUM IMPLANTED FOR 21 DAYS IN 3-WEEK OLD RATS. THE LONG-TERM EFFICACY OF THIS COMPOUND IS CURRENTLY BEING INVESTIGATED. THE OBJECTIVE OF ...

    SBIR Phase I 1989 Department of Health and Human Services

  4. NEW METHOD OF FIXATION OF BIOPROSTHESES

    SBC: Biomedical Design Inc.            Topic: N/A

    GLUTARALDEHYDE-PRESERVED BIOPROSTHESES HAVE BEEN ASSOCIATED WITH IMPORTANT LONG-TERM CLINICAL PROBLEMS SUCH AS STENOSIS, BIODEGRADATION AND CALCIFICATION-INDUCED HEART FAILURE. AN ALTERNATIVE TO THE USE OF GLUTARALDEHYDE, WHICH CONSISTS OF CROSS-LINKING BIOLOGICAL TISSUE BY FORMING STABLE BONDS, WILL BE DEVELOPED. PRELIMINARY DATA SUGGEST THAT THIS NEW PROCESS CROSS-LINKS PORCINE HEART VALVE LEAFL ...

    SBIR Phase II 1994 Department of Health and Human Services

  5. Xenograft Heart Valves--Biomechanics/Collagen Structure

    SBC: CRYOLIFE, INC.            Topic: N/A

    Though allograft human aortic valves are preferred for transplantation by virtue of their lowthrombogenicity and immunogenicity, superior hemodynamic performance, and extended durability, onlyabout 2,000 per year are implanted due to limited donated heart supply. An acellular porcine heart valvecould form the substrate of a heart valve graft after the removal of native cells and soluble proteins t ...

    SBIR Phase I 1994 Department of Health and Human Services

  6. ENGINEERED HEART VALVE--FLOW AND FIBROBLAST FUNCTION

    SBC: CRYOLIFE, INC.            Topic: N/A

    N/A

    SBIR Phase II 1997 Department of Health and Human Services

  7. ENGINEERED HEART VALVE--FLOW AND FIBROBLAST FUNCTION

    SBC: CRYOLIFE, INC.            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services

  8. CRYOPRESERVED ARTERIES AS ALLOGRAFT VASCULAR CONDUIT

    SBC: CRYOLIFE, INC.            Topic: N/A

    N/A

    SBIR Phase I 1997 Department of Health and Human Services

  9. EVALUATION OF CRL1072 FOR TREATMENT OF MYCOBACTERIUM AV

    SBC: CYTRX CORPORATION            Topic: N/A

    N/A

    SBIR Phase II 1997 Department of Health and Human Services

  10. EVALUATION OF CRL1072 FOR TREATMENT OF MYCOBACTERIUM AV

    SBC: CYTRX CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
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