Award Data

PROJECT SUMMARY Glycans have several distinct properties that make them excellent targets for disease biomarkersFirstlytheir location glycans on cell surfaces makes them the first point of contact for cellular interactionsand thus they are crucial in the control of normal metabolic processesSecondlycell surface molecules are also strategically exposed for surveillance by the immune system allowing ...

Project Summary Congenital CytomegalovirusCMVinfection is a leading cause of birth defects and developmental disabilities in the U Saffecting thousands of children each yearCurrent methodse gtissue cultureshell vial assaysingle copy gene PCR methodsetcto detect CMV infections are labor intensive and require sophisticated equipmentdedicated laboratory spaceand trained techniciansA rapidon site test ...

Project SummaryAging increases the risk of GI disorders such as CRCinflammatory bowel diseaseand appendicitisNIH statistic shows thattomillion people are affected by digestive diseasesIncreasing global geriatric population base is expected to further worsen this situation over the coming yearsAnnuallydiseases of the gastrointestinalGItract account for more thanmillion office visits and more thanmi ...

Project Summary The long term goal of this project is to develop validate and commercialize a PCR based molecular test for routine Alzheimer s disease AD testing that will provide more comprehensive risk estimates for disease and offer a superior option for clinical trial assays that can help accelerate drug development This test anticipates the utility of a powerful risk marker in the TOMM ...

Project Summary Abstract This Phase I SBIR proposes to develop and demonstrate the feasibility of an innovative computer based program for training therapists to administer Comprehensive Behavioral Intervention for TicsCBITan empirically supported nonpharmacological intervention for children and adults with Chronic Tic DisordersCTDincluding Tourette DisorderCTD represents a class of neuropsychiatr ...

This project will explore the translational potential of a new PET molecular imaging probe Ga PC for detecting very small cancers and distinguishing between localized and metastasized cancers in bone and soft tissue mouse models Ga PC will be evaluated for metastatic prostate PC and pancreatic PaCa cancers Early detection of the most lethal PaCa with andlt survival for y ...

SUMMARY PhotoSound Technologies Inc proposes to develop a novel imaging modality for characterization and pre clinical research of murine models The technology will be capable of three dimensional functional and molecular imaging of fluorescent labels and reporter genes mapped with high fidelity over robust anatomical structures such as skin central and peripheral vasculature and internal o ...

Project Summary The goal of this project is to significantly enhance our understanding and treatment of inadequate balance responses in the elderly and in patients with neurological impairments following external perturbations such as a slip or trip Our laboratory studies have shown that balance responses can be improved with practice in the elderly and in patients with Parkinsonandapos s disease ...

PROJECT SUMMARY The objective is to discover selective CNS penetrant inhibitors of the kinase responsible for phosphorylation of OLIG and a potential target for treatment of glioblastoma In this proposal Curtana Pharmaceuticals Inc will discover new kinase inhibitors based on findings that prototypical compounds inhibit OLIG phosphorylation and the degree of inhibition is dependent on key asp ...

Project summary This Phase I will establish the feasibility of increasing audiological diagnostic information by carrying out word and phoneme level analyses of open set responses during speech audiometry and by obtaining subjective hearing measures Speech audiometry is used in characterizing functional hearing in settings of hearing screening diagnosis hearing aid fitting counseling aural ...