Award Data

DESCRIPTION (provided by applicant): The scientific literacy of U.S. high school students is disturbingly low, leaving many ill-prepared to comprehend the substance of important modern issues, as well as their own health-related conditions. Enhanced educational efforts are needed to improve the nation's scientific literacy and help more American high school students keep pace with the rapidly ...

DESCRIPTION (provided by applicant): Primorigen will use SBIR SHIFT funds to develop an array system that can identify chemically-defined surfaces to optimize induced pluripotent stem cell (hiPSC) differentiation and maturation. The platform initially willbe validated for its capacty to help increase functional maturity of stem cell-derived hepatocytes, particularly cytochrome p450 (CYP) activity, ...

DESCRIPTION (provided by applicant): Economic, logistical, and physical barriers limit HIV viral load quantification, the gold standard for HIV diagnostics. The cost of the test is high (approximately 100 per test) and the intricate equipment required limits testing to laboratories staffed by highly trained technicians. Also, the labile nature of the biomarker, viral RNA, require testing to be pe ...

DESCRIPTION: Incremental improvements in label free screening technologies over the past decade have not produced the capability necessary to support the changing needs of drug discovery programs. Persistent artifacts related to non-specific binding, promiscuous binding, precipitation, complex binding, tubing retention, aggregation, and sub-optimally designed platforms continue to hinder progress ...

DESCRIPTION: Vascular leak is a hallmark of tissue injury, and results in the movement of plasma into the interstitium where immune mediators and clotting factors invade the injured tissue. Left to persist, vascular leak can exacerbate inflammation and lead to a chronic and abnormal wound healing response. Sphingosine 1-phosphate (S1P) is a pleiotropic lipid mediator that circulates in the bloods ...

Not Available

DESCRIPTION (provided by applicant): Experimental manipulation of gene expression is a widely used technique that is crucial to much of modern biomedical research. The ability to control the timing and expression level of recombinant genes is central to the production of recombinant protein for basic research as well as for the synthesis of biological pharmaceuticals. Commercially available system ...

DESCRIPTION (provided by applicant): This application aims to test a new Scarab E. coli strain, MDS42pdu, for commercial fermentation to produce biopharmaceuticals, amino acids and biofuels. It is designed for a very low rate of point mutations and Insertion Sequence transposition, especially in the stress conditions of recombinant protein production. We propose here to study the impact on a funda ...

DESCRIPTION (provided by applicant): Diuretics are the most widely prescribed class of drugs. As renal function deteriorates in patients with chronic kidney disease (CKD) whose glomerular filtration rate falls below 60 ml/min (stages 3 to 5) they become more salt-sensitive and require a low BP goal to slow the progression of their disease and to prevent the associated cardiovascular disease (CV) c ...

DESCRIPTION (provided by applicant): Healing of Diabetic Ulcers with Gaseous Nitric Oxide Generated from Room Air Diabetic foot ulcers (DFUs) are a frequent and debilitating complication of diabetes, and affect 1-2.5 million patients in the US. Many DFUs remain unhealed, leading to extensive hospitalizations and the increased risk of infections, amputations, and death. Patients with DFUs that do n ...