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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic

    SBC: Laser Tissue Welding, Inc            Topic: NIDDK

    DESCRIPTION (provided by applicant): Preservation of functioning renal parenchyma is important and nephron-sparing surgery substitutes for radical nephrectomy in appropriately selected patients with renal cell carcinoma. Laparoscopic partial nephrectomy (LPN) has demonstrated excellent outcomes in terms of oncologic control, but is under-used due to major technical challenges of parenchymal hemost ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  2. Adhesion Signature-Based, Label-Free Isolation of Pluripotent Stem Cell Derived N

    SBC: ARUNA BIO, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Currently, up to one billion people worldwide suffer from disabling neurodegenerative disorders, including traumatic injuries, stroke and diseases of the CNS such as Alzheimer's and Parkinson's disease (PD). As the number of afflicted individuals substantially grows, it is imperative that more sophisticated, biologically relevant cellular model system ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  3. Web-Based CBT for Childhood Anxiety: A Family-Led Approach

    SBC: VIRTUALLY BETTER INC            Topic: NIMH

    DESCRIPTION (provided by applicant): Anxiety Disorders are some of the most commonly occurring psychological disorders among child and adolescent populations. Cognitive-Behavioral Therapy (CBT) has been proven to be an Evidence-Based Treatment (EBT) to treat anxiety, but there continues to be a lack of available CBT resources for families with anxious youth. Technology-based interventions, includi ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  4. Optimization of Novel NR2C and NR2D subunit-selective NMDA receptor potentiators

    SBC: NEUROP, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Schizophrenia is a chronic neurological disorder that affects approximately 1% of the world population and causes gt 60 billion dollars of direct and indirect societal costs in the US alone (Wu et al., 2005). Current therapies to treat this disorder have been effective in ameliorating positive symptoms (hallucinations, delusions, irrational fear), but are le ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  5. FIV Testing of a CNS-Relevant Antiretroviral Compound

    SBC: Jericho Sciences, LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): Specific Aims Neurological complications of HIV-1/AIDS persist despite HAART therapies. Current knowledge identifies several sources of neuronal aggravation: (1) direct virus infection of astrocytes and microglial cells; (2) infiltratin of virus-infected monocyte/macrophages; (3) cytokine dysregulation indirectly affecting nerve cells; (4) breakdown of the blo ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  6. Site-specific O-GlcNAc MAbs: New Tools for Glycoproteomics

    SBC: GLYCOSCIENTIFIC, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): O-glycosylation of serine and threonine of nuclear and cytoplasmic proteins by a single beta-N- acetyl-D-glucosamine moiety (O-GlcNAc) is a ubiquitous post-translational modification that is highly dynamic and fluctuates in response to cellular stimuli. O-GlcNAc often competes with protein phosphorylation, and these two modifications have extensive crosstalk in ...

    STTR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  7. A novel live intranasal TB vaccine

    SBC: PATHENS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The most-widely used vaccine for TB currently is BCG, a live avirulent variant of M. bovis that is given intradermally at birth. Along with the inherent safety and logistical problems associated with being injected, protective efficacy is generally poor and wanes by adolescence. BCG administration to an immunosuppressed individual also can disseminate and lead ...

    STTR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  8. TITER ON CHIP: ALTERNATIVE TO SRID FOR INFLUENZA VACCINE POTENCY DETERMINATION

    SBC: INDEVR, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): There is a tremendous need for new analytical methods to enhance vaccine research and development, ultimately allowing the production of safe and efficacious vaccines in less time at less cost. For example, it is well known that for splt vaccines one step in the process that can be rate limiting is protein quantification and potency determination. The FDA appro ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  9. Point-of-Care Diagnostic Test for Entamoeba histolytica Cysts

    SBC: TECHLAB, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The NIAID Category B priority pathogen Entamoeba histolytica is a public health threat, especially as a cause of diarrhea in travelers to and immigrants from endemic areas, men who have sex with men, and children in thedeveloping world where it is in the top 5 causes of severe diarrhea. It is also a biodefense threat to water and food supplies due to its resist ...

    STTR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  10. A novel 3D microscope for imaging and photostimulation

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Mental disease, including schizophrenia, depression and autism spectrum disorders, are still poorly understood, although it is clear that they mostly represent cortical disorders. The cortex is the primary site of higher mental functions, and despite extensive research, there is still no unified theory of how the cortex works. This is partl due to the fact that ...

    STTR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
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