Award Data

DESCRIPTION (provided by applicant): Glycosyltransferases involved in linking polyketide macrolactones with deoxysugars are key enzymes for combinatorial biosynthesis of novel macrolide anti-infective agents. In this proposal, a new gene shuffling technology, RACHITT, is applied to the desosarninyl transferase (Des VII) from the pikromycin biosynthetic pathway of Strept ...

DESCRIPTION (Scanned from the Applicant's Abstract): Blockade of A2B adenosine receptors (A2BARs) increases insulin sensitivity in insulin resistant obese Zucker rats by an effect on skeletal muscle. We have synthesized and characterized the first potent and selective antagonists of A2B receptors. The goal of this phase I SBIR proposal is to develop improved A2 ...

DESCRIPTION: (Adapted from the Investigator's Abstract): Adenosine administered as an aerosol to asthmatics causes bronchoconstriction, while in non-asthmatics adenosine causes bronchodilation. This occurs because the activation of A2B adenosine receptors on sensitized mast cells triggers degranulation, releasing histamine, leukotrienes, and other allergic mediators. A2B a ...

The purpose of this research is to develop and test the feasibility of a novel portable computerized system that will enable nursing assistants to provide improved patient care. The system will enable nursing assistants to work more efficiently, record data more accurately, and spend more time with each patient. The system is being designed for use in assisted living facilities and nursing home ...

Environmental degradation of adhesive bonds of composite or metallic structures affects predominantly the adhesive/adherent interface by decreasing the number of molecular bonds between the adhesive and the substrate. The objective of the proposed Phase I work is to perform a feasibility study of a novel non-linear ultrasonic method for quantitative characterization of molecular bond density with ...

The intelligence community is hampered in its ability to provide information to a gamut of users. The critical shortfalls are database access, timely data fusion, robust dissemination techniques, and communications bandwidth. This effort will create adynamic and responsive intelligence architecture to include; multiple database access, support dynamic user profiling through intelligent agents, p ...

A program is proposed that will extend (and build upon) the work already started by the Survivability Group of the Composites Affordability Initiative, Pervasive Team in developing methods for analyzing the effects of ballistic and hydrodynamic ram (HRAM)loading and damage in bonded/co-cured composite structures.Specifically, the objective will be to remedy a major shortcoming of current HRAM fini ...

ABI's innovation is a novel centrifugal pump, which will not have bearings, shaft, and seals. The impeller in this pump would rotate in a stable position in the center of the pump housing. The balance of all hydodynamic forces acting on impeller achieves stability. This pump will have high reliability, durability, and low cost in reduced mass, power and volume configuration, which are required in ...

The realization of future space transportation systems and hypersonic aircraft will need the use of ceramic matrix composites that are economical and can withstand high thermomechanical and aerodynamical loads. Advanced Ceramics Research, Inc. (ACR) has recently developed a rapid prototyping process for its patented C3 continuous fiber reinforced ceramic composites for high temperature application ...

Military and commercial entities desire multifunctional or