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THE OBJECTIVE OF THIS PROGRAM IS TO DEVELOP A LOW-COST, FIBEROPTICALLY COUPLED RAMAN SPECTROMETER FOR BIOLOGICAL, BIOCHEMICAL, BIOPHYSICAL, AND CLINICAL APPLICATIONS. RAMAN SPECTROSCOPY PROVIDES MOLECULAR FINGERPRINTING CAPABILITIES AS DOES INFRARED SPECTROSCOPY, BUT UNLIKE INFRARED, RAMAN ISAPPLICABLE TO AQUEOUS ENVIRONMENTS. THE PROPOSED INSTRUMENTWILL PROVIDE THE SCIENTIFIC COMMUNITY WITH A FLE ...

The Department of Defense and their contractors are currently limited in their ability to fabricate high temperature thermal protection and structural materials and include those materials in new aerospace vehicle designs without risk of thermally induced material failures which might compromise the new designs. Major improvements in structural designs will be difficult without cost effective mat ...

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DESCRIPTION: Cancer treatment by gene therapy, in which an exogenous gene is introduced into tumor cells, is receiving increasing attention. Metabolism of a specific substrate by the enzyme encoded by the transduced gene produces a substance toxic to the tumor. In the most common approach, the gene for the Herpes Virus Thymidine Kinase has been introduced by retroviral transduction. Although p ...

The problem facing many U. S. high temperature material vendors is the high cost and long span times required for testing with "conventional" techniques. The higher the heat flux required for the test, the more expensive the test, and the more elaborate the facility required. The cost and schedule required for testing by "conventional" means becomes a global competitiveness problem for U. S. hig ...

Efforts to apply active noise and vibration control commercially, while intensifying, continue to be hampered by the cost of the computers required to implement the active algorithms. Currently, the cost of wide-band control is prohibitive for lightly damped systems such as precision structures or highly reverberant acoustic spaces, even if the system has just one canceling actuator and one error ...

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A progressive system development is proposed which uses Bayesian methodology for combined detect, track, localize, and classify. The core paradigm focuses on detection followed by various estimation schemes to extract information on contact type, track, and location from the detector. A rapid prototype development using the Generic Multipurpose Processor (GMP) will provide optimal detection ...