Award Data

DESCRIPTION (provided by applicant): This fast-track proposal applies advanced kinetic image pattern recognition (KIPR) technologies to predict induced pluripotent stem cell (iPSC) reprogramming colonies' differentiation outcomes for significantly improvedyield and robustness of differentiation protocols. The objectives of the proposed tool are 1) Teaching: creation of scores for induced colo ...

DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is mediated by articular expression of pro-inflammatory cytokines and chemokines. We have discovered that the purine degradation product inosine exerts multiple anti-inflammatory and immunomodulatory effects via combined A2a and A3 agonism, resulting in suppressed expression of TNF-alpha, IL-1 beta, IL-12, MIP-lalpha, and IFN-gamma an ...

Abstract Chronic phantom limb painPLPhas been reported to inflict as many asof people with amputationsPLP is described as feeling like burningtwistingitchingor pressure in part of the missing limbThese painful sensations have a substantial negative impact on quality of lifepeople who suffer PLP have high rates of depressiondifficulty sleepingregular absences from workdissociation with family frien ...

In this SBIR FastTrack proposalMicro Leads will develop HDa high resolutionchannel spinal cord stimulation therapy to provide more pain relief with greater specificity for those suffering from chronic neuropathic pain and opioid dependenceOvermillion in the U Ssuffer from debilitating pain in the trunk and extremities anddepend on opioids to ease their sufferingOpioid abuse has claimed the lives o ...

ABSTRACT Chronic perforations of the tympanic membraneTMaffect overpatients in the United States annuallyoften stemming from ventilation tubes inserted in the TM to drain fluid from middle ear infectionsLeft untreatedthese TM perforations can lead to significant morbidities that include recurrent ear infectionconductive and sensorineural hearing lossmastoid bone infectionand cholesteatoma developm ...

DESCRIPTION (provided by applicant): Individuals with intellectual and developmental disabilities (I/DD) have more untreated caries and a higher prevalence of gingivitis and other periodontal diseases than the general population (NIDCR, 2009). In order to address this health care disparity, more dentists are needed who understand and are trained to meet the needs of this population. Few in-depth ...

Project Summary/AbstractThe objective of this Phase I Socially-Assistive Robots for Alzheimer’s (SARA) effort is to design and demonstrate the feasibility of a socially integrative and supportive robot system to enhance the connectedness, caregiving, well-being, and quality of life of older adults experiencing early to middle stage Alzheimer’s disease (AD) and AD-related dementias (ADRD). One ...

DESCRIPTION (provided by investigator): Burkholderia pseudomallei is a bioterrorist threat. With the best current therapies, lethality is typically as high as 40%. The overall goal of this application is the development of new drugs against this organism. In Phase I, we will exploit the high sequence similarity between B. pseudomallei and its less virulent relative Pseudomonas aeruginosa to build ...

DESCRIPTION (provided by applicant): Conventional microscope bulbs burn out, degrade, and produce a great deal of unnecessary light and heat. For fluorescence microscopy and imaging, only monochromatic, narrow band spectra are generally required, yet with conventional microscopy light sources a significant amount of light and heat is discarded. Solid state, Light Emitting Diode (LED) illuminati ...

Project Summary Functional drug fingerprinting with all-optical electrophysiology The Optopatch platform recently developed at Q-State Biosciences, which uses engineered optogenetic proteins, custom microscopes, and software, makes it possible to simultaneously stimulate (blue light) and record (red light) electrical activity from ~100 neurons with 1 millisecond temporal resolution, single-cell sp ...