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An ideal transistor from a circuit designers standpoint consists of an ultra-low on-resistance, majority carrier switching, low gate current drive, and normally-off design. These features are inherent in the silicon carbide (SiC) power MOSFET, with the small footnote that the device, although having surpassed many hurdles along the way, is still plagued by a few key issues that limit commercial ad ...

APEI, Inc. is proposing in this Phase I effort to design and build a scalable, high-efficiency, high-power density, gallium nitride (GaN)-based DC-DC converter for grid-tied energy storage applications. The project approach will utilize a soft switching dual active bridge DC-DC converter with state-of-the-art GaN power semiconductor switches and advanced power packaging techniques to efficiently t ...

This Small Business Technology Transfer (STTR) Phase I project aims to develop an efficient, rapid, and eco-friendly approach for mass production of highly conductive solution phase graphene with controlled structures. Most of the commercial available solution phase conductive graphene sheets are either highly defective reduced graphene oxide (r-GO) or non-defective pristine graphene sheets. They ...

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will investigate the technical feasibility of an in vitro excystation-based automated cartridge assay for rapid detection of viable Cryptosporidium oocysts in water. Briefly, viable oocysts will be subjected to an in vitro excystation step to release sporozoites and the antigens for detection on a patent-p ...

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop an effective protein replacement therapeutic (PRT) for patients affected with rare forms of Osteogenesis imperfecta, OI-VIII (deficiency in prolyl 3-hydroxylase 1; P3H1)and OI-VII (deficiency in cartilage associated protein CRTAP). These PRTs will integrate the safety and cost advantages of plant-based bioproduct ...

DESCRIPTION (provided by applicant): There are approximately 4 million Americans with severe speech and physical impairments (SSPIs) who must rely on augmentative and alternative communication (AAC) systems to express themselves. People with SSPI are at asignificant disadvantage when communicating. AAC systems place heavy cognitive and physical demands on users, resulting in very slow communicatio ...

DESCRIPTION (provided by applicant): There are currently mutations in over 200 genes that have been described to cause kidney disease. Current strategies for diagnosis of genetic kidney disease are extremely costly and time consuming. We aim to develop a comprehensive next generation sequencing panel that can simultaneously test for all currently described kidney- associated gene mutations at a lo ...

DESCRIPTION (provided by applicant): Physical activity may improve the health and quality of life of people with spinal cord injury and disease (SCI/D) by slowing or reversing physiological decline, lowering risk factors for cardiovascular disease and diabetes, improving mental health status and independence, and promoting the efficient performance of daily activities. Unfortunately, lack of acc ...