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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. ClearScope

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    Combined in vivo and ex vivo three dimensionalDwhole brain imaging of non transgenic and transgenic animal models holds the promise of novel insights into neural network connectivity patternsWith regard to ex vivo light microscopic imaging ofD whole brain datasetsthe best approach is brain clearing followed by whole brain light sheet microscopyLSMbecause of its unique combination of speedD resolvi ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Development of an Enhanced, Simplified Blood Coagulation Test to Monitor Patients on Direct Oral Anti-Coagulants

    SBC: Haematologic Technologies, Inc.            Topic: NHLBI

    Project SummaryOver the lastyearsDirect Oral AnticoagulantsDOACshave become increasingly prevalent for treating patients with cardiovascular disorders because of their pharmacokinetic stability and lack of interaction with certain foodsYetthere is increasing evidence of improper dosing in a small proportion of treated patientsand growing recognition of the need to develop simpleinexpensive tests t ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Neuroinformatics platform using machine learning and content-based image retrieval for neuroscience image data

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    This project aims to develop NeuroManageran innovative neuroinformatics platform for advanced parsingstoringaggregatinganalyzing and sharing of complex neuroscience image dataA core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using SemanticsICARUSa novelintelligent neuroimage curation system that will enable image retrieval based on visual appearanc ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment

    SBC: Healthy Design Ltd. Co.            Topic: NIA

    ABSTRACT The goal of this Fast Track STTR project is to optimize and test a novel arm restraint in older critically ill mechanically ventilated patients that increases mobilityreduces agitationuse of sedative medicationsand deliriumand exhibits high satisfaction and acceptability among hospital stafffamily membersand patientsOlder mechanically ventilated patients are often immobilized with wrist r ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Evaluating the Comparative Validity and Reliability of SERAS A Decision Support Tool for Assessing Near Term Risk of Suicide in Emergency Departments

    SBC: Wiser Systems LLC            Topic: 104

    PROJECT SUMMARY The goal of the NIMH Zero Suicide Initiative is prevention of suicide among individuals being served by health care systems The Products to Support Applied Research Towards Zero Suicide Healthcare Systems FOA specifically calls for development of health IT products designed to meet this goal Our Systematic Expert Risk Assessment of Suicide SERAS is a neural network based dec ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Patient Engagement Alcohol Risk Reduction System PEARRS

    SBC: VERMEDX, INC.            Topic: 450

    PROJECT SUMMARY ABSTRACT Over a quarter of primary care patients in the United States can be classified as unhealthy drinkers because their alcohol use conveys a high risk of health and social consequences Unfortunately unhealthy drinking is under recognized in spite of the existence of valid screening tools Even when unhealthy drinking is recognized barriers such as provider discomfort shor ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. On-Line Reading Instruction Dynamically Adapted to Low-Achieving Students’ Motivation and Engagement

    SBC: TAYLOR ASSOCIATES COMMUNICATIONS INC            Topic: NICHD

    DESCRIPTION provided by applicant The goal of this project is to increase reading motivation engagement and proficiency in struggling readers Literacy is essential to academic success responsible citizenship and optimal health through the lifespan Research has shown that the motivation to read in the early grades is a significant predictor of later literacy outcoms an effect largely medi ...

    SBIR Phase I 2016 Department of Health and Human Services
  8. System for monitoring the neural activity of freely moving C. elegans

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    DESCRIPTION provided by applicant As a highly used model organism Caenorhabditis elegans C elegans worms offer a wide range of possibilities for scientific research With advantages including but not limited to easy maintenance and handling forward and reverse genetic manipulability and a fully mapped nervous system connectome of neurons C elegans offer a high throughput alternati ...

    SBIR Phase I 2016 Department of Health and Human Services
  9. System for advanced automated 3D microvascular analysis in neuroplasticity

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    Abstract It has become evident that the microvasculaturei emicroscopically small blood vesselsplays a critical role in the plasticity of the brain for fundamental processesineurogenesisiimigration of neuronal precursors to their final destination in the brainiiiaxonaldendritic and synaptic plasticity during brain developmentlearningaging and neurodegenerationandivrecovery from traumatic brain inju ...

    SBIR Phase II 2016 Department of Health and Human Services
  10. Automated 3D quantitative analysis of dendritic spines imaged with light microscopy

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    Abstract This project aims to develop a novel systemSpines InvestigatorTMfor performing automated four dimensionalDquantitative analysis of changes in dendritic spine morphology on three dimensionalDmicroscopic images acquired with in vivo multiphoton fluorescence microscopy at different time pointsThe role of dendritic spines is one of the most active and important areas of neuroscience researchP ...

    SBIR Phase II 2016 Department of Health and Human Services

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