Award Data

This Small Business Innovation Research (SBIR) Phase II project will focus on the development of a commercial process for the growth of Neodymium Yttrium Vanadate (Nd: YVO4) single crystals for use in solid-state lasers. This research will generate the commercially viable conditions for growth of large boules of single crystals suitable for use in diode pumped solid-state lasers. The hydrothermal ...

Building upon the Edelman's Neural Darwinism and Damasio's brain model, we propose a framework for creating evolutionary and neurobiologically inspired computational platforms for autonomous vehicle control as well as for applications in the arena of ambient intelligence. Additionally, we propose this framework within a larger one that includes sensor and actuator interfaces together with a commun ...

An increasingly common military medical need is the need for in-the-field acquisition of symptomatology, differential diagnosis of diseases potentially previously unseen by the medical professional, and identification of symptoms to the population at large. This need suggests a combination of intelligent diagnostic decision aids and knowledge gathering agents overlaid onto a highly flexible physio ...

DESCRIPTION (provided by applicant): This is the follow-on Phase II SBIR proposal to continue the project Novel Neurotensin Analogs as Antischizophrenics (MH-65099) under PA-06-079 (Pharmacological Agents and Drugs for Mental Disorders). There exists a critical clinical need for the identification and development of novel therapies for psychosis, a major unmet medical need. Low levels of the bra ...

The development of a process to produce low defect density silicon carbide (SiC) boules at high growth rates will significantly reduce the cost of wafers and thus accelerate the rapid commercialization of SiC for high power and high temperature device applications. The objectives of this Phase II project is to improve the process development of a radically new approach to grow bulk SiC of a singl ...

This Small Business Innovation Research (SBIR) project will develop a highly accurate temperature measurement system that can be used in optimizing the growth of high brightness light emitting diodes for solid state lighting applications. This product does not currently exist due to technical difficulties in measuring the substrate or gallium nitride (GaN) epilayer in a region where they ab ...

DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the "Edmonton protocol". However, at this time, procurement of donor pancreases for islet isolation and transplantation is in its infancy. Most pancreases at more remote donor sites are not procured due to justifi ...

DESCRIPTION (provided by applicant): The overall objective of this proposal is to define the hypothermic storage conditions and shelf life for tissue engineered cartilage constructs (TECCs) required for commercial manufacturing and distribution. Preliminary studies employing TECCs have demonstrated that chondrocyte viability and construct biochemistry were significantly impacted by hypothermic sto ...

DESCRIPTION (provided by applicant): In-vitro drug testing on precision-cut liver slices (PCLS) provides the most realistic biochemical metabolic profile of in-situ conditions for predicting drug toxicity and metabolism during early stage drug development. An ample supply of cryopreserved human liver slices obtained from viable donor livers and hepatic resects of split liver transplant surgerie ...

Proposed work addresses the stated objective "Intelligently decipher text strings and determine when one Work Unit Code is related to a National Stock Number" while also advancing toward twin higher goals: more productive maintenance and better control of part inventories. Tasks include (1) Identification of some indentured parts, (2) Integration of some maintenance databases, (3) Correlation of W ...