Award Data

We propose to use physiological sensors to measure the quality of a trainee's interaction with a virtual environment (VE) as a function of VE fidelity to enable design improvements in VEs and to enhance training effectiveness through feedback of physiological-based performance information. Currently, VE design is guided by subjective design models that involve multiple design iterations and focus ...

DESCRIPTION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesothelioma (MM). These pathways are critical to MM cell proliferation and chemoresistance. Our initial research suggests that APMS will be significantly more eff ...

DESCRIPTION (provided by applicant): A collaborative effort between ASL Analytical, Inc. and a research team at the University of Iowa is proposed to development a noninvasive nocturnal hypoglycemic alarm. The goal for the alarm system is to provide continuous noninvasive measurements during the sleep period of an individual with diabetes, sounding an audible alarm to wake the person if an impe ...

Current ASW missions require low frequency off-board sound sources that can operate monostatically or bistatically. Since these sources may or may not be recoverable, and may require a substantial number to cover the designated operating areas, the low frequency source transducers also need to be low cost. The team of Etrema Products and Applied Research Laboratory at The Pennsylvania State Univ ...

The size of conventional split ring transducers is much smaller than a wavelength at operating frequency leading to a high Q resonance and limited operating bandwidth. The proposed work will investigate two different modifications to the split ring structure that allow its resonance frequency to be adjusted under active control so that it is always operated at or near its resonance. Because the ...

DESCRIPTION (provided by applicant): Phase I funding for this project supported successful studies that were aimed at demonstrating the feasibility of developing an easy to use, global test in the arena of clinical hemostasis that would be sensitive to antithrombotic drugs, bleeding disorders and thrombotic pathologies. This test comprises a measurement of the rate of thrombin generation and/or to ...

This Small Business Technology Transfer (STTR) Phase I project aims to develop a novel chemistry to prepare metal fluorides by the direct reaction of metals with fluorocarbons. The new process is highly suited to the manufacture of: (1) wires for optical communications; (2) high-surface-area metal fluoride catalysts used in the generation of fluoropolymers; and, (3) optical thin films such as an ...

The objective of this proposal is to develop a reliable method to obtain reduced-order models for the simulation of large-scale seismic and acoustic signature propagation. These reduced-order models should be capable of reproducing results comparable to those obtained from a high-fidelity high-performance geologically complex numerical simulation code that normally requires a massively parallel c ...

DESCRIPTION (provided by applicant): The overall goal of the proposed studies is to establish the feasibility of developing therapies for brain cancers such as glioblastoma multiforme from the schweinfurthin family of antiproliferative agents. These agents are highly toxic to CNS derived tumor cell lines in vitro and more importantly appear to exhibit this activity via a novel cellular target(s). ...

DESCRIPTION (provided by applicant): The overall goal of the proposed studies is to establish the feasibility of moving our novel class of GGDPS specific inhibitors into clinical development for treatment of myeloma and metastatic disease of the bone. The specificity that a number of these novel non-nitrogen- containing bisphosphonates, most notably LWS-138, exhibit over the leading commercial alt ...