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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a Humanized Pig Model of Cystic Fibrosis

    SBC: EXEMPLAR GENETICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most CF patients have a mutation that deletes phenylalanine 508 (?F508) and prevents CFTR from being properly processed and delivered to cell membr ...

    SBIR Phase I 2008 Department of Health and Human Services
  2. Gene Silencing with U1 Adaptor Oligonucleotides

    SBC: INTEGRATED DNA TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively al ter the expression level of any desired gene has been a goal of both scientists and clinicians for years. Historically, the most common approac ...

    SBIR Phase I 2008 Department of Health and Human Services
  3. Improved influenza A virus vaccines using alpha-Gal epitope modification

    SBC: NEWLINK GENETICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Humans develop natural antibodies against a sugar molecule called Gal, which is present on proteins and lipids in most other species. These antibodies represent one of the strongest natural barriers to infection with ba cteria, parasites and viruses. NewLink Genetics has licensed this technology as the HyperAcute(c) vaccine and it is in Phase I and II clinical ...

    SBIR Phase I 2008 Department of Health and Human Services
  4. Development of Novel Neuroprotective Agents for Parkinson?s Disease

    SBC: PK Biosciences Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by progressive and substantial loss of dopaminergic neurons in the substantia nigra compacta (SNc), resulting in severe neurological si gns including tremors, bradykinesia, and rigidity. The existing approaches to PD treatment are mainly focused on alleviating the motor symptoms ...

    SBIR Phase I 2008 Department of Health and Human Services
  5. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  6. Noninvasive Nocturnal Hypoglycemic Alarm

    SBC: ASL Analytical, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): A collaborative effort between ASL Analytical, Inc. and a research team at the University of Iowa is proposed to development a noninvasive nocturnal hypoglycemic alarm. The goal for the alarm system is to provide continuous noninvasive measurements during the sleep period of an individual with diabetes, sounding an audible alarm to wake the person if an impe ...

    STTR Phase I 2007 Department of Health and Human Services
  7. BIODEGRADABLE MAGNESIUM STENTS WITH FINE MICROSTRUCTURE

    SBC: INDIVIDUAL AWARD--SHECHTMAN, DAN            Topic: N/A

    N/A

    SBIR Phase I 2007 Department of Health and Human Services
  8. Predicting stability of nucleic acid duplexes containing chemical modifications

    SBC: INTEGRATED DNA TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Synthetic DNA and RNA oligomers are important tools for biological and medical assays including polymerase chain reactions, sequencing, DNA microarrays, antisense technology and RNA interference. Oligomers are generally used in experiments where they anneal to complementary sequences. Accurate predictions of annealing processes and duplex stability are therefor ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. Novel Glioblastoma Therapeutics

    SBC: TERPENOID THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of the proposed studies is to establish the feasibility of developing therapies for brain cancers such as glioblastoma multiforme from the schweinfurthin family of antiproliferative agents. These agents are highly toxic to CNS derived tumor cell lines in vitro and more importantly appear to exhibit this activity via a novel cellular target(s). ...

    STTR Phase I 2007 Department of Health and Human Services
  10. Preclinical Development of Geranylgeranyl Disphosphate Synthase Inhibitors as Ant

    SBC: TERPENOID THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of the proposed studies is to establish the feasibility of moving our novel class of GGDPS specific inhibitors into clinical development for treatment of myeloma and metastatic disease of the bone. The specificity that a number of these novel non-nitrogen- containing bisphosphonates, most notably LWS-138, exhibit over the leading commercial alt ...

    STTR Phase I 2007 Department of Health and Human Services

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