List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Targeting Deceoy Receptor 3 in Breast Cancer

    SBC: BIOPOWERTECH            Topic: N/A

    DESCRIPTION (provided by applicant): Breast cancer is the leading cause of cancer deaths in the United States. In this year alone, approximately 40,480 women in the US are estimated to die from breast cancer. In most cases, death results from metastasis of breast cancer cells. Cancer patients with metastasis cannot currently be cured. Therefore, the invention of therapy to treat breast cancer met ...

    SBIR Phase I 2008 Department of Health and Human Services
  2. Near-Infrared Nanopolymer Agents for Real-Time, In Vivo Imaging of Tumor Margins

    SBC: CFD Research Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Optical imaging as a noninvasive diagnosis technique is a highly promising tool for real-time, in-vivo detection of tumor margins during breast-conserving surgery. This can decrease false-negative diagnoses and local re currences of the cancer that occur after conventional diagnoses and lumpectomy. Its clinical application has been held back by lack of suitable ...

    SBIR Phase I 2008 Department of Health and Human Services
  3. A Simulation Tool to Enable Identification of Critical Network Interactions Using

    SBC: CFD Research Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): One of the main challenges in the discovery of intracellular biomarkers and identification of therapeutic targets is the lack of a mechanistic understanding of the complex underlying pathways. The tremendous increase in both the quantity and diversity of cellular data represents a significant challenge to researchers seeking to construct biologically relevant ...

    SBIR Phase I 2008 Department of Health and Human Services
  4. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis

    SBC: DISCOVERYBIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis Scientific Summary Description Hypertension is a confounding multifactorial disorder that affects millions of patients worldwide. Cystic fibrosis (CF) is an inherited disease of the pulmonary and gastrointestinal systems that presents in pediatric and young adult populations. What do hypertension ...

    SBIR Phase I 2008 Department of Health and Human Services
  5. MRI Detection, Lateralization, and Quantification of Mesial Temporal Lobe Epileps

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop and commercialize a software package to be interfaced with commercial MRI scanners providing physicians with an immediately available diagnostic tool for noninvasive detec tion, lateralization, and quantification of epileptogenic tissue. This software would convert a set of 2D MRI images of the brain to a 3D perce ...

    SBIR Phase I 2008 Department of Health and Human Services
  6. Development of a Humanized Pig Model of Cystic Fibrosis

    SBC: EXEMPLAR GENETICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most CF patients have a mutation that deletes phenylalanine 508 (?F508) and prevents CFTR from being properly processed and delivered to cell membr ...

    SBIR Phase I 2008 Department of Health and Human Services
  7. Fluorescence Anisotropy-based Macromolecule Crystallization Screening

    SBC: IXPRESSGENES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Current practice is to set up trial crystallization screens and periodically review the results to see if a crystal or promising crystal-like precipitate has appeared a process that often takes weeks or months. Most out comes are precipitated protein or clear drops, and the conditions that led to those results are dropped from further consideration. We propose ...

    SBIR Phase I 2008 Department of Health and Human Services
  8. Delivery system development for a reservoir targeted Lyme disease vaccine

    SBC: FoodSource Lure Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The incidence and geographic distribution of Lyme disease in the U.S. has increased steadily since its first description in 1977. Efforts to stem the spread of the disease through controlling the population of its tick vector and/or the mouse reservoirs of the disease have met with only limited success. The only approved human vaccine to protect against Lyme d ...

    STTR Phase I 2008 Department of Health and Human Services
  9. Gene Silencing with U1 Adaptor Oligonucleotides

    SBC: INTEGRATED DNA TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively al ter the expression level of any desired gene has been a goal of both scientists and clinicians for years. Historically, the most common approac ...

    SBIR Phase I 2008 Department of Health and Human Services
  10. Improved influenza A virus vaccines using alpha-Gal epitope modification

    SBC: NEWLINK GENETICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Humans develop natural antibodies against a sugar molecule called Gal, which is present on proteins and lipids in most other species. These antibodies represent one of the strongest natural barriers to infection with ba cteria, parasites and viruses. NewLink Genetics has licensed this technology as the HyperAcute(c) vaccine and it is in Phase I and II clinical ...

    SBIR Phase I 2008 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government