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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Targeting Deceoy Receptor 3 in Breast Cancer

    SBC: BIOPOWERTECH            Topic: N/A

    DESCRIPTION (provided by applicant): Breast cancer is the leading cause of cancer deaths in the United States. In this year alone, approximately 40,480 women in the US are estimated to die from breast cancer. In most cases, death results from metastasis of breast cancer cells. Cancer patients with metastasis cannot currently be cured. Therefore, the invention of therapy to treat breast cancer met ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  2. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  3. Development of a Database Management System to Enable Rapid, Efficient Assay Design for Use in Detection and Diagnosis of Human Exposure to Biological

    SBC: CFD RESEARCH CORPORATION            Topic: CBD07114

    Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

    SBIR Phase II 2008 Department of DefenseOffice for Chemical and Biological Defense
  4. Near-Infrared Nanopolymer Agents for Real-Time, In Vivo Imaging of Tumor Margins

    SBC: CFD RESEARCH CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Optical imaging as a noninvasive diagnosis technique is a highly promising tool for real-time, in-vivo detection of tumor margins during breast-conserving surgery. This can decrease false-negative diagnoses and local re currences of the cancer that occur after conventional diagnoses and lumpectomy. Its clinical application has been held back by lack of suitable ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  5. A Simulation Tool to Enable Identification of Critical Network Interactions Using

    SBC: CFD RESEARCH CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): One of the main challenges in the discovery of intracellular biomarkers and identification of therapeutic targets is the lack of a mechanistic understanding of the complex underlying pathways. The tremendous increase in both the quantity and diversity of cellular data represents a significant challenge to researchers seeking to construct biologically relevant ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis

    SBC: DISCOVERYBIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis Scientific Summary Description Hypertension is a confounding multifactorial disorder that affects millions of patients worldwide. Cystic fibrosis (CF) is an inherited disease of the pulmonary and gastrointestinal systems that presents in pediatric and young adult populations. What do hypertension ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. MRI Detection, Lateralization, and Quantification of Mesial Temporal Lobe Epileps

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop and commercialize a software package to be interfaced with commercial MRI scanners providing physicians with an immediately available diagnostic tool for noninvasive detec tion, lateralization, and quantification of epileptogenic tissue. This software would convert a set of 2D MRI images of the brain to a 3D perce ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Humanized Pig Model of Cystic Fibrosis

    SBC: EXEMPLAR GENETICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most CF patients have a mutation that deletes phenylalanine 508 (?F508) and prevents CFTR from being properly processed and delivered to cell membr ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  9. Fluorescence Anisotropy-based Macromolecule Crystallization Screening

    SBC: iXpressGenes, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Current practice is to set up trial crystallization screens and periodically review the results to see if a crystal or promising crystal-like precipitate has appeared a process that often takes weeks or months. Most out comes are precipitated protein or clear drops, and the conditions that led to those results are dropped from further consideration. We propose ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  10. Delivery system development for a reservoir targeted Lyme disease vaccine

    SBC: FoodSource Lure Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The incidence and geographic distribution of Lyme disease in the U.S. has increased steadily since its first description in 1977. Efforts to stem the spread of the disease through controlling the population of its tick vector and/or the mouse reservoirs of the disease have met with only limited success. The only approved human vaccine to protect against Lyme d ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
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