Award Data

The Small Business Innovation Research (SBIR) Phase I project will investigate the feasibility of developing autonomic-healing hot mix asphalt. A major objective of this proposed study is to develop self-healing hot mix asphalt (by means of phase-dispersion of healing agent) that would actively arrest microcracks. This study will involve mechanical tests to determine the healing efficiency of auto ...

AED Corp., C-K Technologies, Control Systems inc, and Digital-Engines will structure and focus their collective expertise to design, optimize technologies, build, test, and develop a 650-hp advanced diesel technologies demonstrator. The work will be supported by AED’s Phase II Advanced Military Diesel Engine (AMDE) program. During Phase I this team of experts incorporated AMDE design feature ...

Today’s Warfighter often carries an inordinate load that can lead to injuries and encumbered performance. Equipment is distributed among squad members with little, if any regard for differences in strength and anthropometry. Consequently, the current focus on human-centric design requires a modeling and simulation tool that can reduce the load Warfighters carry and can help distribute equipmen ...

DESCRIPTION (provided by applicant): A growing number of potential native and engineered biothreat agents effectively limit the proactive protection of public health through vaccination. An alternative approach relies on the use of corresponding protective antibodies that are pre-made and are used as injectable drugs in reactive rather than proactive mode. The implementation of this approach, how ...

Aniuk Consulting, LLC, proposes to create a GIS software toolkit for monitoring areal snow cover extent and producing streamflow forecasts. This toolkit will be packaged as multiple extensions for ArcGIS 9.2 and provides users with a means for easily ingesting NASA EOS satellite images (for snow cover analysis), preparing hydrologic model inputs, and visualizing streamflow forecasts. Primary pro ...

DESCRIPTION (provided by applicant): We were originally awarded SBIR grant R43AT003183-01 in September 2005 to develop a miniature, wireless skin conductance monitor to measure hot flash frequency and severity. A prototype monitor was developed that measur es changes in sternal skin conductance and uses pattern recognition software to recognize the frequency, and timing of hot flashes. The electro ...

DESCRIPTION (provided by applicant): Methylation is a ubiquitous and reversible covalent modification used to control the function of diverse biomolecules including their activity, stability and localization. Like phosphorylation, methylation is used to mo dulate protein function, but in addition many small molecules are regulated by methylation including hormones, neurotransmitters, xenobiotics, ...

DESCRIPTION (provided by applicant): There is a high level of pharmaceutical interest in targeting enzymes that catalyze oxidation and reduction reactions for therapeutic intervention. Validated redox enzyme targets include HMG-CoA reductase, the target of statin drugs like Lipitor that are used to treat hypercholesterolemia, and 51-reductase, the target of drugs used to treat benign prostatic hy ...

DESCRIPTION (provided by applicant): In less than one year the 1918 Spanish flu pandemic claimed over 20 million lives worldwide, killing 675,000 Americans, more than 10 times the number of deaths to US servicemen in World War I. A similar strain of the vi rus that caused the 1918 pandemic could today kill 2 million Americans and force 10 million to be hospitalized. Although anti-viral drugs are k ...

This Small Business Innovation Research Phase I project is for the development of technology to crystallize proteins using less sample and with higher speed and success than current high throughput protein crystallization methods. Protein crystallization is an intermediate step in determining the precise three-dimensional shape of a protein, and proteins are involved in virtually every cellular pr ...