Award Data

This Small Business Innovative Research Phase I project builds on a research program investigating the design of process-based software development tools and methodologies. The project will develop a next generation of this software that supports the creation, refinement, and adaptation of software development methodologies in a principled manner while preserving the need for rapid innovation. Th ...

This Small Business Innovation Research Phase I project initiates rigorous investigation of automated pattern recognition in images produced by comprehensive two-dimensional gas chromatography. Comprehensive two-dimensional gas chromatography (GCxGC) is an emerging technology for chemical separation that provides a multiplicative increase in separation capacity over traditional GC. With this grea ...

This Small Business Innovation Research (SBIR) Phase II project proposes to use bioinformatics to transform complex data produced by comprehensive two-dimensional gas chromatography with mass spectrometry (GCxGC-MS) to usable chemical information. GCxGC-MS is an emerging technology for chemical separations that provides an order-of-magnitude increase in separation capacity over traditional GC. Re ...

NON-TECHNICAL SUMMARY: Over application of nitrogen fertilizer on agricultural and commecial landscapes has resulted in contamination of ground and surface waters. This project proposes to develop a new sensor technolgy that will help reduce the amount of N applied to crops and turf by determining the amount of N needed by the plant via the plants reflectance characteristics.

NON-TECHNICAL SUMMARY: Over application of nitrogen fertilizer on agricultural and commecial landscapes has resulted in contamination of ground and surface waters. This project proposes to develop a new sensor technolgy that will help reduce the amount of N applied to crops and turf by determining the amount of N needed by the plant via the plants reflectance characteristics.

DESCRIPTION (provided by applicant): We have been developing a system for real-time single molecule DNA sequencing. System components include novel "charge-switched" nucleotides, an adapted DNA polymerase, a method for isolating and handling single DNA molecules, a microfluidics flowcell for sorting molecules by charge, a TIR (total internal reflection) optical system for single-molecule detection ...

NON-TECHNICAL SUMMARY: General methods to produce uniform capsules with well-defined and controllable shell thickness and diameter, especially at the nano- and micro-scale, are in great demand for controlled and timed release of drugs, agrochemicals, nutraceuticals, and probiotics. The proposed technique should in principle allow encapsulation of all such types of valuable agents, e.g., agrochemic ...

DESCRIPTION: Novel continuous, non-woven oxide nanofibers will be used to design, produce and test a new class of allceramic materials for restorative Dental applications. The working hypothesis is that these new nanofiber/glass systems will be of significantly higher mechanical quality than state-of-the-art technologies used in the field. Two materials scientists (Drs. Dzenis and Larsen, co-PI an ...

DESCRIPTION (provided by applicant): Mouse VL30 (retrotransposon) long terminal repeats (LTRs) are a potential source of tissue-specific transcriptional promoters that can be used to deliver and express therapeutic genes in humans. Such vectors are badly needed, because the current retroviral vectors appear to be effective only in hematopoietic cells in vivo. In phase I, a retro-vector system will ...

There is great anticipation and an urgent need to develop a low viscosity, affordable, non-styrene based, flame resistant resin system similar to the vinyl ester Derekane 510A and curable at room temperature. This resin system, compliments of DowChemical, is a Brominated bisphenol and has work quite well relative to confined place. There is a need to find an alternate material that will produce n ...