Award Data

DESCRIPTION (provided by applicant): Tumor antigen primed dendritic cells (DCs) are under widespread clinical evaluation for immunotherapy of multiple forms of cancer. Emerging evidence suggests that DCs are fundamental regulators of the immune response

DESCRIPTION (provided by applicant): Malignant melanoma is a significant and deadly form of cancer worldwide. Emerging evidence has shown that melanoma cells express tumor-associated antigens that are specifically recognized by the immune system. Melanom

DESCRIPTION (provided by applicant): The purpose of this study will be to detect the prevalence and prognostic value of plaque temperature heterogeneity in diabetic patients undergoing stent implantation. The objective is to develop and commercialize a

DESCRIPTION (provided by applicant): The purpose of this study will be to detect the prevalence and prognostic value of plaque temperature heterogeneity in diabetic patients undergoing stent implantation. The objective is to develop and commercialize an intraluminal Thermal Sensing System (TSS) for taking surface temperature measurements of atherosclerotic plaque lesions within the walls of cor ...

This Phase II SBIR will demonstrate the feasibility of applying spectral beam combining (SBC) to large mode area fibers to enable power scaling to the 100kW level while maintaining the excellent beam quality provided by a single fiber laser. The anticipated result of the Phase II and the Phase II option will be the laboratory demonstration of a beam-combined fiber laser system, and the subsequent ...

73137-Future active imaging systems for national security applications (for remote reconnaissance, monitoring and characterization of hard targets, and compact surveillance devices) require compact, rugged, and efficient short-pulse laser sources that can operate over a wide-repetition-rate range. To deploy these devices on ground, air, and space platforms, the new laser sources are required to i ...

The purpose of this program is to develop a compact and efficient ultraviolet laser system for ozone sensing from space. The basis for this system will be a diode-pumped neodymium-yttria (Nd:Y2O3) laser which is frequency-tripled to generate uv light at either 305nm or 315nm. The ability to generate both uv wavelengths from a single frequency-tripled Nd:Y2O3 laser makes this approach potentially 4 ...

We propose a Yb:S-FAP laser system that will provide over 1 J per pulse output at 100 Hz with excellent beam quality and high efficiency, in a package far more compact, and lighter weight than conventional laser systems. The proposed laser system uses design approaches compatible with space-qualification. The high-pulse-energy power oscillator architecture is especially suited to space platforms ...

NIST is using a sensitive optical technique called cavity ring-down detection to permit detection of impurities in semiconductor process gases, which cause substantial losses in manufacturing yield. In order to increase the sensitivity and range of application of this technique, improved single frequency laser sources are required. In particular, lasers providing more power, narrower line-width, b ...

Optically pumped, high power, mid-Infrared semiconductor lasers that operate at cryogenic temperature must be engineered to operate over large ambient temperature and harsh vibration environments to be able to be used in future IRCM systems. The proposed work will demonstrate novel methods of laser packaging that enable operation of a low cost, mid-infrared, semiconductor laser in military tempe ...