Award Data

Abstract for Supplement ApplicationThe ultimate goal for our original project was to complete the proof-of-concept work, and the multitude of pharmacodynamic, pharmacokinetic, toxicokinetic, safety, and toxicology studies required by the FDA to apply for an IND. We are fully satisfied that we have generated a new chemical entity that acts at a novel binding site on the GABA-A receptor and acts in ...

The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

Ferrium M54 is an ultrahigh-strength, high, toughness steel with high resistance to grinding burn damage, and stress corrosion cracking, which provides many technical and commercial benefits for use in the F-18 E/F/G hook point application over the incumbent 4330V steel. The technical advantages for risk mitigation, while extending the component life at approximately the same cost makes for a good ...

The primary objective of this SBIR initiative is to develop, demonstrate, and validate new manufacturing technologies. The focus is complex parts made from refractory metals manufactured at reduced costs and increased fabrication rates. The target components are for use in post-boost control system (PBCS) hot-gas valves and manifolds. Emphasis on and addressing scale up for fabrication of full-sca ...

This SBIR Phase I project aims to prove the technical feasibility and the economic viability of natural fiber welded and dyed yarns and fabrics. Natural fiber welding is process that swells and mobilizes polymers within natural fibers to create higher performance yarns and fabrics. At sufficiently fast rates, individual fibers are fused and bonded together without glues or resins while retaining a ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop and bring to market tools that improve code quality and help avoid dangerous bugs, while also improving programmer productivity. Poor code quality leads to bugs which often translate into financial loses and can even endanger human life. A study by NIST estimated software bugs co ...

Many applications involved in real-time data collection need to monitor their data while it is being collected- This need occurs in a large and growing number of applications that use common scientific hierarchical data formats for data management, such as aircraft flight testing, autonomous vehicles, particle accelerators, and many more- There are two shortcomings to these formats that make it di ...

As the world continues to rely more heavily on connectivity, it becomes more and more imperative that the networks that support the technical applications leverage intelligence to guide the network operations management- These networks and the applications that utilize them produce massive complex data that range from structured, unstructured, geo‐spatial, images, real and historical to name a f ...

Next generation rare isotope beam facilities will be a critical component of the Department of Energy mission to understand the fundamental forces and particles of nature manifested in nuclear matter- These facilities require a huge financial investment for construction, and it is crucial to achieve and maintain maximum operation efficiency to enable uninterrupted use of the facilities- In produci ...

Lack of availability, usability, and the cost of development, ownership, and operation of high performance compute-ready simulation capabilities are significant barriersto utilization of modeling & simulation for American industry- Most open-source, free technologies are difficult to use and/or not validated to the extent needed for industrial application-Many commercial tools that are easy to use ...