Award Data

This SBIR Phase I project addresses a critical need in medicine ? the ability to deliver drugs selectively to parts of the body that need medication. Targeted drug delivery improves patient outcomes by treating tissues locally while reducing overall exposure and side effects elsewhere. For example, a cream or lotion type product which moves anti-inflammatory drugs through skin specifically to an a ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project lies in its potential to develop a new mechanism for painlessly terminating atrial fibrillation. Cardiac arrhythmia is one of the leading causes of death and debilitation. A common means of terminating harmful rhythms is delivering a shock via an external or implantable defibrillator. The pain ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop a hyper-personalized, clinical, and evidence-based blood transfusion decision support tool to reduce unnecessary transfusions, transfusion-related complications, and transfusion related expenditures. Blood transfusions are the most commonly prescribed medical procedure in the US, ...

This project develops a mobile device and/or web-based coaching tool that provides evidence-based therapeutic strategies for children with anxiety disorders with the goal to improve independence and participation in daily activities. Anxiety disorders are among the most common childhood mental health diagnoses with lifetime prevalence rates ranging from 15% to 20%. Additionally, anxiety disorders ...

This project seeks to develop, manufacture, and evaluate a novel nervous system simulation platform consisting of freely connectable electronic neuron modules. These devices will be used in the secondary education and post-secondary education classroom to further students? conceptual grasp of neuroscience, engineering, and physiology, and to generate lasting enthusiasm for a career path centered o ...

This project will enable students to learn difficult science concepts using a collaborative gaming approach that aims to significantly increase student engagement and understanding. This game is being developed to improve the instruction of photosynthesis and cell respiration, which are required curriculum for high school students in life science courses. These processes are largely invisible, com ...

Abstract Non viral gene delivery is used in most biomedical laboratories for basic research and for many commercial and medical applications These include basic investigations into gene function modification of cells for the production of recombinant proteins and generation of genetically modified human cells for cancer therapy e g chimeric antigen receptor transgenic T cells However the d ...

Project Summary Abstract Advanced Medical ElectronicsAMEproposes the development of a novel portable wireless hearing aid accessory that utilizes head pose and eye tracking of the hearing aid user to steer a microphone array in the direction of interestA common problem for hearing aid users is the difficulty of participating in conversations in a noisy environment such as at a workplace or restaur ...

Validation of a Novel Therapeutic Approach for Cryptococcal Meningitis PILadShivanand and McCabeAaron Project Summary When Cryptococcus is manifested as cryptococcal meningitisCMit creates a large burden of mortality and morbidity to the patient and is very difficult for the clinician to treatThere are now an estimatedUS cases andcases of CM worldwide annuallywith estimated mortality ofper yearCM ...

Abstract In this Phase I SBIR Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume P V in rodent studies Transgenic models of heart disease have been created through hypothesis driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the develop ...