Award Data

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is that the proposed delivery system will advance many RNA therapeutic solutions to address intimal hyperplasia (IH) and other vascular conditions. Vascular disease is the most common disease pathology in the US, costing the country’s healthcare system over $437 billion dollars annually. Bec ...

There is a large, unmet need for an energy-efficient, facility-scale mobility system that addresses the needs of underserved communities, particularly people with reduced mobility (PRM). Mobility services in airports and other large facilities, are failing to meet the needs of PRM due to rapidly scaling demand and fragmented systems that remain heavily reliant on manual labor and unreliable commun ...

PROJECT SUMMARY We propose to develop a novel non-contact, label-free multimodality imager that provides real-time intraoperative identification of nerves within the surgical field-of-view to facilitate the prevention of unintended nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical complications, e.g., chronic pain. In the United St ...

Abstract There is an unmet need to develop treatments for senile osteoporosis, a disorder characterized by an age-related reciprocal decrease in osteogenesis and increase in bone marrow fat. Senile osteoporosis resembles disuse osteopenia, suggesting its pathogenesis involves impaired bone mechanosensing. We discovered that the polycystin heterotrimeric complex (1PC1+3PC2) functions as a mechanose ...

Project SummaryEpilepsy is one of the most common brain disorders. Current drugs have limited efficacy. Identifying new targeted drugs that can be used as safer, more effective therapies is in urgent unmet need. Selective inhibition of the transient receptor potential canonical 3 (TRPC3) emerges as a novel strategy to impede epilepsy. However, the currently best selective TRPC3 inhibitor, Pyr3, ha ...

Electromagnetic Interface (EMI) Shielding is critical for maintenance of critical infrastructure and to prevent from external signals from disrupting electronics devices.  State of the art EMI shielding includes heavy metal-based materials, which add mass

Semiconducting carbon nanotubes (s-CNTs) have been used to build thin, flexible sensors relevant to the DoD mission. These include both physical sensors, such as stress/strain and temperature sensors, and chemical sensors, such as biomarker or toxic compo

In this STTR effort, SkyNano will collaborate with Prof. Hongyu Zhou's laboratory at the University of Tennessee Knoxville (UTK) to demonstrate the utilization of environmental carbon in composite applications specific to meeting the needs of the Department of the Navy.  SkyNano will leverage our core technology which captures and converts environmental carbon dioxide into functional all-carbon ...

Carbon fiber is now used extensively in military vehicles, structures and equipment, and its use will only expand due to its combination of light weight and high strength. However, the challenge of widespread adoption both in the military and in the comme

Chemical sensors based on functionalized carbon nanotubes (CNTs) have been demonstrated to detect battlefield-relevant biomarkers and other analytes. This includes quantification of neurological and cardiological stress markers as well as detection of har