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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 4397 results
  1. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: Molecular Targeting Technologies, Inc.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 363: myCare2- Supporting Caregivers and Caregiving

    SBC: BRIGHTOUTCOME INC.            Topic: NCI

    The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 364: SysMet: Integrative Systems Metabolomics

    SBC: OmicsCraft LLC            Topic: NCI

    Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 360: A SIMPLE END-TO-END SYSTEM FOR SERIAL CELL SORTING AND MANIPULATION USING A SINGLE CONTAINER

    SBC: DIAGNOLOGIX, LLC            Topic: NCI

    Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Plasma-Enhancement of Absorbers for Improved Removal of PFOS and PFOA from Water

    SBC: AA Plasma LLC            Topic: 17NCER1A

    New regulations and advisory levels for perfluoroalkyl substances have resulted in increased drinking water treatment costs or abandonment of drinking water sources. Treatment technologies are needed that can achieve low parts-per-trillion levels. Presently, there are insufficient treatment technologies that can destructively remove perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonic aci ...

    SBIR Phase I 2018 Environmental Protection Agency
  7. An Enhanced Contact Plasma Reactor: A Competitive Remediation Technology for Per- and Perfluoroalkyl Substance (PFAS) Contaminated Water

    SBC: Dmax Plasma LLC            Topic: 17NCER1A

    Perfluoroalkyl substances (PFASs) have received considerable attention due to their toxicity, ubiquitous presence and recalcitrance. Manufacture and disposal of PFAS-containing products has resulted in PFAS contamination of numerous water supplies. Recent reports indicate the Air Force alone is expecting to spend > $2.25 billion for cleanup for PFAS-contaminated sites. Thus, there is a huge market ...

    SBIR Phase I 2018 Environmental Protection Agency
  8. Capacitive removal of PFOA and PFOS from Drinking Water

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: 17NCER1A

    Polyfluoroalkyl and perfluoroalkyl compounds (PFCs) have been used commercially since the 1940’s due to their high level of chemical stability, almost frictionless surface or waterproofing characteristics. Elevated levels of PFCs have been linked to cancer and other health problems including reproductive and developmental risks. PFOA and PFOS are amongst the most prevalent of the PFCs with low l ...

    SBIR Phase I 2018 Environmental Protection Agency
  9. Replacements for PVC and PE Water Pipes

    SBC: MATERIALS ENGINEERING AND TECHNICAL SUPPORT SERVICES CORP.            Topic: 17NCER1C

    METSS proposes to design a novel polymer system based on polypropylene with covalently attached antioxidants to mitigate issues with chemical permeation and water quality with current waterpipe materials. Polypropylene was selected as it has inherently good physical properties and low permeability that will limit chemical migration from the outside, addressing one critical factor impacting water q ...

    SBIR Phase I 2018 Environmental Protection Agency
  10. Drone-Based Gas Mapping LiDAR for Leak Mitigation

    SBC: Bridger Photonics, Inc.            Topic: 17NCER2C

    Bridger Photonics, Inc. proposes developing a drone-based Gas Mapping LiDAR™ sensor to mitigate the loss of valuable product across the Oil & Gas supply chain.The sensor will uncover leaks and physical changes to infrastructure and pipeline right-of-ways using high-resolution 3D topographical imagery with methane gas concentration overlays.The technology will enable reliable detection, precise l ...

    SBIR Phase I 2018 Environmental Protection Agency

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